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Article
CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-κB Complexes
Molecular Cell
  • Seung J. Kim, London Regional Cancer Program
  • Samuel Asfaha, London Regional Cancer Program
  • Frederick A. Dick, London Regional Cancer Program
Document Type
Article
Publication Date
1-3-2019
URL with Digital Object Identifier
10.1016/j.molcel.2018.12.012
Abstract

PD-L1 plays a central role in immune recognition of cancer cells. In this issue of Molecular Cell, Jin et al. (2019) report that a phosphorylated retinoblastoma protein contacts the DNA-binding domain of p65 NF-κB, thereby blocking transcription of PD-L1.

Citation Information
Seung J. Kim, Samuel Asfaha and Frederick A. Dick. "CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-κB Complexes" Molecular Cell Vol. 73 Iss. 1 (2019) p. 1 - 2
Available at: http://works.bepress.com/samuel-asfaha/6/