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Selected Works of Samuel Asfaha
Article
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Cancer Cell
  • Yoku Hayakawa, Vagelos College of Physicians and Surgeons
  • Hiroshi Ariyama, Vagelos College of Physicians and Surgeons
  • Jitka Stancikova, Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic
  • Kosuke Sakitani, Vagelos College of Physicians and Surgeons
  • Samuel Asfaha, Vagelos College of Physicians and Surgeons
  • Bernhard W. Renz, Vagelos College of Physicians and Surgeons
  • Zinaida A. Dubeykovskaya, Vagelos College of Physicians and Surgeons
  • Wataru Shibata, Vagelos College of Physicians and Surgeons
  • Hongshan Wang, Vagelos College of Physicians and Surgeons
  • Christoph B. Westphalen, Vagelos College of Physicians and Surgeons
  • Xiaowei Chen, Vagelos College of Physicians and Surgeons
  • Yoshihiro Takemoto, Vagelos College of Physicians and Surgeons
  • Woosook Kim, Vagelos College of Physicians and Surgeons
  • Shradha S. Khurana, Vagelos College of Physicians and Surgeons
  • Yagnesh Tailor, Vagelos College of Physicians and Surgeons
  • Karan Nagar, Vagelos College of Physicians and Surgeons
  • Hiroyuki Tomita, Graduate School of Medicine
  • Akira Hara, Graduate School of Medicine
  • Antonia R. Sepulveda, Vagelos College of Physicians and Surgeons
  • Wanda Setlik, Vagelos College of Physicians and Surgeons
  • Michael D. Gershon, Vagelos College of Physicians and Surgeons
  • Subhrajit Saha, Albert Einstein College of Medicine of Yeshiva University
  • Lei Ding, Vagelos College of Physicians and Surgeons
  • Zeli Shen, Massachusetts Institute of Technology
  • James G. Fox, Massachusetts Institute of Technology
  • Richard A. Friedman, Vagelos College of Physicians and Surgeons
  • Stephen F. Konieczny, Purdue Center for Cancer Research
  • Daniel L. Worthley, Vagelos College of Physicians and Surgeons
  • Vladimir Korinek, Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic
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Document Type
Article
Publication Date
12-14-2015
URL with Digital Object Identifier
10.1016/j.ccell.2015.10.003
Abstract

The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1+ stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. Diffuse-type cancer development is dependent on inflammation mediated by Cxcl12+ endothelial cells and Cxcr4+ gastric innate lymphoid cells (ILCs). These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates RhoA to inhibit anoikis in the E-cadherin-depleted cells. Targeting Cxcr4, ILCs, or Wnt5a inhibits diffuse-type gastric carcinogenesis, providing targets within the neoplastic gastric stem cell niche.

Citation Information
Yoku Hayakawa, Hiroshi Ariyama, Jitka Stancikova, Kosuke Sakitani, et al.. "Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche" Cancer Cell Vol. 28 Iss. 6 (2015) p. 800 - 814
Available at: http://works.bepress.com/samuel-asfaha/20/