The methanolic extract of Ficus platyphylla Del.-Holl. stem bark was investigated for anti-inflammatory and anti-nociceptive activities. The anti-inflammatory activity was tested against egg albumin-induced edema, while the analgesic effects were studied using the acetic acid-induced writhing in mice and formalin test in mice. The results revealed that the aqueous extract of Ficus platyphylla possess significant, dose dependent anti-inflammatory effects. The extract also inhibited pain caused by acetic acid in mice and reduced pain episodes induced by formalin. The intraperitoneal LD50 in mice was 2000 mg/kg.