As an important voice in genetic and molecular anthropology, Fatimah Jackson has challenged race science and modeled ethical, methodological, and analytical responsibility in relation to the role of race and exclusion in anthropology. She has published innovative research on ecology, plant–human–animal interactions, health, and disease, particularly in her commitment to studying malaria and its abatement. In this conversation, Jackson shares her frank assessments of the racism and sexism she has faced. Current events and day-to-day life shaped her outlook and cultivated her curiosities, as did her involvement in key scientific achievements, such as the Human Genome and Human Genome Diversity Projects. These trials and tribulations were not merely challenges to transcend or leave behind. They were central to her experiences, first as a student and then as a scholar, shaping her commitments to science, scholarship, and pedagogy. In this interview, the interweaving of biography and science that makes Jackson's pedagogy so distinctive also marks her reflections on her career.