A Nutritional Formulation for Cognitive performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label ExtensionJournal of Alzheimer's Disease (2015)
Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0.7) and maintained baseline performance in CLOX-1. The placebo cohort did not improve in DRS and declined in CLOX-1, but during the open-label extension improved in DRS and ceased declining in CLOX-1. These findings extend prior studies of NF efficacy for individuals without cognitive impairment and with Alzheimer’s disease.
- Alzheimer's disease,
- cognitive performance,
- mild cognitive impairment,
Citation InformationRuth Remington, Jevin Lortie J., Heather Hoffman, Robert Page, et al.. "A Nutritional Formulation for Cognitive performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension" Journal of Alzheimer's Disease Vol. 48 Iss. 3 (2015) p. 591 - 595
Available at: http://works.bepress.com/ruth_remington/26/
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