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Maintenance of cognitive performance and mood for individuals with Alzheimer's disease following consumption of a nutraceutical formulation: a one-year, open-label study
Journal of Alzheimer's Disease (2016)
  • Ruth Remington
  • Cynthia Bechtel, Framingham State University
  • David W. Larsen
  • Annemarie Samar, Framingham State University
  • Robert Page
  • Christopher Morrell
  • Thomas Shea
Abstract
Nutritional interventions have shown varied efficacy on cognitive performance during Alzheimer’s disease (AD).
Twenty-four individuals diagnosed with AD received a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) under open-label conditions (ClinicalTrials.gov
NCT01320527). Primary outcome was cognitive performance. Secondary outcomes were behavioral and psychological symptoms of dementia (BPSD) and activities of daily living. Participants maintained their baseline cognitive performance and BPSD over 12 months. These findings are consistent with improvement in cognitive performance and BPSD in prior placebo-controlled studies with NF, and contrast with the routine decline for participants receiving placebo.
Keywords
  • Alzheimer’s disease,
  • behavioral symptoms,
  • cognitive performance,
  • mood,
  • nutraceutical formulation
Disciplines
Publication Date
2016
Publisher Statement
Published article:
Remington, R., Bechtel, C., Larsen,D., Samar, A., Page, R., Morrell, C., Shea, T. B. (2016) Maintenance of cognitive performance and mood for individuals with Alzheimer's disease following consumption of a nutraceutical formulation: A one-year, open-label study. Journal of Alzheimer's Disease: JAD, 51(4), 991-995. doi: 10.3233/JAD-151098
Citation Information
Ruth Remington, Cynthia Bechtel, David W. Larsen, Annemarie Samar, et al.. "Maintenance of cognitive performance and mood for individuals with Alzheimer's disease following consumption of a nutraceutical formulation: a one-year, open-label study" Journal of Alzheimer's Disease (2016)
Available at: http://works.bepress.com/ruth_remington/25/
Creative Commons license
Creative Commons License
This work is licensed under a Creative Commons CC_BY-NC-ND International License.