Skip to main content
Article
Efficacy of a Vitamin/Nutriceutical Formulation for Moderate to Late Alzheimer’s Disease: A Placebo-controlled Pilot Study
American Journal of Alzheimer’s Disease & Other Dementias
  • Ruth Remington, Framingham State University
  • A Chan
  • Thomas B Shea
Document Type
Article
Publication Date
2-1-2009
DOI
10.1177/1533317508325094
Version
Citation
Format
Other
Keywords
  • Activities of Daily Living/psychology,
  • Affect/drug effects,
  • Aged,
  • Aged,
  • 80 and over,
  • Alzheimer Disease/diagnosis,
  • Alzheimer Disease/drug therapy,
  • Alzheimer Disease/physiopathology,
  • Chemistry,
  • Pharmaceutical,
  • Cognition/drug effects,
  • Cohort Studies,
  • Dietary Supplements,
  • Drug Therapy,
  • Combination,
  • Humans,
  • Pilot Projects,
  • Severity of Illness Index,
  • Treatment Outcome,
  • Vitamins/therapeutic use
Subject Categories
Nursing
Disciplines
Abstract

Recent studies demonstrated efficacy of a vitamin/ nutriceutical formulation (folate, vitamin B12, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl-L-carnitine) for mild to moderate Alzheimer's disease. Herein, we tested the efficacy of this formulation in a small cohort of 12 institutionalized patients diagnosed with moderate-stage to later-stage Alzheimer's disease. Participants were randomly separated into treatment of placebo groups. Participants receiving the formulation demonstrated a clinically significant delay in decline in the Dementia Rating Scale and clock-drawing test as compared to those receiving placebo. Institutional caregivers reported approximately 30% improvement in the Neuropyschiatric Inventory and maintenance of performance in the Alzheimer's Disease Cooperative Study-Activities of Daily Living for more than 9 months. This formulation holds promise for delaying the decline in cognition, mood, and daily function that accompanies the progression of Alzheimer's disease, and may be particularly useful as a supplement for pharmacological approaches during later stages of this disorder. A larger trial is warranted.

Citation Information
Ruth Remington, A Chan and Thomas B Shea. "Efficacy of a Vitamin/Nutriceutical Formulation for Moderate to Late Alzheimer’s Disease: A Placebo-controlled Pilot Study" American Journal of Alzheimer’s Disease & Other Dementias Vol. 24 Iss. 6 (2009) p. 27 - 33
Available at: http://works.bepress.com/ruth_remington/22/