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Article
Influence of dietary phytochemicals and microbiota on colon cancer risk.
Journal of Agricultural and Food Chemistry
  • Ruth S. MacDonald, Iowa State University
  • Kelly Wagner, Iowa State University
Document Type
Article
Publication Date
5-25-2012
DOI
10.1021/jf204230r
Abstract
Colon cancer is the third most commonly diagnosed type of cancer in the United States. Lifestyle and dietary patterns influence colon cancer risk both positively and negatively. Among the dietary factors, several plant-derived compounds have been found to afford colon cancer protection. These compounds potentially influence all aspects of colonic cellular regulation and develop complex interrelationships with the colonic microbiome. Increasing understanding of the role of microorganisms in determining the colonic environment has led to awareness of this important interrelationship among dietary factors and the microbial population. Plant-derived polyphenols are active mediators of cellular events, target key carcinogenic pathways, and modulate colonic microbial populations. In turn, the colonic microorganisms metabolize dietary compounds and mediate cellular events. In addition, the role of estrogen receptors in colon cancer and the importance of dietary components that mediate estrogen receptor-β are increasingly being discovered. Hence, dietary bioactive compounds and the intestinal microbiota create a complex milieu that directly affects the carcinogenic events of the colon. These relationships must be carefully characterized in future research to provide dietary recommendations that will reduce colon cancer risk.
Comments

Reprinted with permission from Journal of Agricultural and Food Chemistry, 60(27): 6728-6735. doi: 10.1021/jf204230r. Copyright 2012 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
Date Available
10/20/2014
File Format
application/pdf
Citation Information
Ruth S. MacDonald and Kelly Wagner. "Influence of dietary phytochemicals and microbiota on colon cancer risk." Journal of Agricultural and Food Chemistry Vol. 60 Iss. 27 (2012) p. 6728 - 6735
Available at: http://works.bepress.com/ruth_macdonald/2/