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Article
Pilot study of vitamin D supplementation in adults with cystic fibrosis pulmonary exacerbation: A randomized, controlled trial
Dermato-Endocrinology
  • Ruth E. Grossmann, University of Iowa
  • Susu M Zughaier
  • Meena Kumari
  • Shabnam Seydafkan
  • Robert H Lyles
  • Shuling Liu
  • Viranuj Sueblinvong
  • Michael S Schechter
  • Arlene A Stecenko
  • Thomas R Ziegler
  • Vin Tangpricha
Document Type
Article
Peer Reviewed
1
Publication Date
4-1-2012
NLM Title Abbreviation
Dermatoendocrinol
PubMed ID
PMC3427199
DOI of Published Version
10.4161/derm.20332
Abstract

Background: Vitamin D insufficiency is common in cystic fibrosis (CF) and vitamin D repletion may have an important role in improving clinical outcomes in CF. This randomized, placebo-controlled, pilot study examined the feasibility and impact of a single, large dose of cholecalciferol on vitamin D status and clinical outcomes in subjects with CF.

Methods: Thirty adults with were randomized in a double-blinded, pilot study to receive 250,000 IU cholecalciferol or placebo within 48 h of hospital admission for a pulmonary exacerbation. Concentrations of 25-hydroxyvitamin D (25(OH)D), clinical outcomes and potential adverse events were assessed up to one year after randomization. Mixed effects linear regression models were used to evaluate the difference in mean serum concentrations and log-rank analyses were used to evaluate survival.

Results: Data from all subjects was analyzed. Serum 25(OH)D concentrations increased from a mean of 30.6 ± 3.2 ng/mL to 58.1 ± 3.5 ng/mL (p < 0.001) at one week and 36.7 ± 2.6 ng/mL by 12 weeks (p = 0.06) in the vitamin D group; in contrast, serum 25(OH)D concentrations remained unchanged in the placebo group. Unadjusted, one-year survival and hospital-free days were increased in the vitamin D group (p = 0.029, p = 0.036; respectively). There was also a trend toward increased IV antibiotic therapy-free days in the vitamin D group (p = 0.073). There were no signs of hypervitaminosis D or adverse events. Serum PTH and calcium concentrations were similar across both groups.

Conclusions: In this pilot study, a single, oral bolus of cholecalciferol increased serum 25(OH)D concentrations and was associated with a trend toward improved clinical outcomes in CF subjects hospitalized for a pulmonary exacerbation. Further investigation is needed into the clinical impact of improved vitamin D status in patients with CF.

Keywords
  • vitamin D,
  • cystic fibrosis,
  • parathyroid hormone,
  • anti-microbial peptide,
  • pulmonary exacerbation
Published Article/Book Citation

Dermato-Endocrinology, 4:2 (2012) pp.191-197. DOI:10.4161/derm.20332

Disciplines
Citation Information
Ruth E. Grossmann, Susu M Zughaier, Meena Kumari, Shabnam Seydafkan, et al.. "Pilot study of vitamin D supplementation in adults with cystic fibrosis pulmonary exacerbation: A randomized, controlled trial" Dermato-Endocrinology Vol. 4 Iss. 2 (2012) p. 191 - 197
Available at: http://works.bepress.com/ruth_grossmann/7/