Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studiesAdvances in nutrition (Bethesda, Md.)
NLM Title AbbreviationAdv Nutr
DOI of Published Version10.3945/an.111.000398
AbstractVitamin D is classically recognized for its role in calcium homeostasis and skeletal metabolism. Over the last few decades, vitamin D deficiency has increased in prevalence in adults and children. Potential extraskeletal effects of vitamin D have been under investigation for several diseases. Several cross-sectional studies have associated lower vitamin D status with decreased lung function. This finding has prompted investigators to examine the association of vitamin D deficiency with several chronic lung diseases. One major focus has been the link between maternal vitamin D status and childhood asthma. Vitamin D deficiency has also been associated with increased risk of respiratory infection from influenza A and Mycobacterium tuberculosis. Other chronic respiratory diseases associated with vitamin D deficiency include cystic fibrosis, interstitial lung disease, and chronic obstructive pulmonary disease. This review will examine the current clinical literature and potential mechanisms of vitamin D in various pulmonary diseases.
- Chronic Disease,
- Cystic Fibrosis/physiopathology,
- Influenza A virus,
- Lung Diseases,
- Mycobacterium tuberculosis,
- Respiratory Tract Infections/microbiology/physiopathology,
- Severity of Illness Index,
- Vitamin D Deficiency/complications/physiopathology
Published Article/Book CitationAdvances in nutrition (Bethesda, Md.), 2:3 (2011) pp.244-253. DOI:10.3945/an.111.000398.
Citation InformationJ. D. Finklea, Ruth E. Grossmann and V. Tangpricha. "Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies" Advances in nutrition (Bethesda, Md.) Vol. 2 Iss. 3 (2011) p. 244 - 253 ISSN: 2156-5376
Available at: http://works.bepress.com/ruth_grossmann/4/