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Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies
Advances in nutrition (Bethesda, Md.)
  • J. D. Finklea
  • Ruth E. Grossmann, University of Iowa
  • V. Tangpricha
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
Adv Nutr
PubMed ID
DOI of Published Version
Vitamin D is classically recognized for its role in calcium homeostasis and skeletal metabolism. Over the last few decades, vitamin D deficiency has increased in prevalence in adults and children. Potential extraskeletal effects of vitamin D have been under investigation for several diseases. Several cross-sectional studies have associated lower vitamin D status with decreased lung function. This finding has prompted investigators to examine the association of vitamin D deficiency with several chronic lung diseases. One major focus has been the link between maternal vitamin D status and childhood asthma. Vitamin D deficiency has also been associated with increased risk of respiratory infection from influenza A and Mycobacterium tuberculosis. Other chronic respiratory diseases associated with vitamin D deficiency include cystic fibrosis, interstitial lung disease, and chronic obstructive pulmonary disease. This review will examine the current clinical literature and potential mechanisms of vitamin D in various pulmonary diseases.
  • Asthma/physiopathology,
  • Chronic Disease,
  • Cystic Fibrosis/physiopathology,
  • Humans,
  • Influenza A virus,
  • Lung/physiopathology,
  • Lung Diseases,
  • Interstitial/physiopathology,
  • Mycobacterium tuberculosis,
  • Respiratory Tract Infections/microbiology/physiopathology,
  • Severity of Illness Index,
  • Vitamin D Deficiency/complications/physiopathology
Published Article/Book Citation
Advances in nutrition (Bethesda, Md.), 2:3 (2011) pp.244-253. DOI:10.3945/an.111.000398.
Citation Information
J. D. Finklea, Ruth E. Grossmann and V. Tangpricha. "Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies" Advances in nutrition (Bethesda, Md.) Vol. 2 Iss. 3 (2011) p. 244 - 253 ISSN: 2156-5376
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