A total of 505 paleomagnetic samples were collected from 65 sites (volcanic flows) of the Patagonian plateau basalts at four locations in southern Chile and Argentina. K/Ar analyses indicate that 38 flows from two locations form a Late Cretaceous group (64–79 Ma), while the remaining 27 flows are Eocene in age (42–56 Ma). Progressive demagnetization indicates that a characteristic remanent magnetization (ChRM) has been successfully isolated from 59 flows. Rock-magnetic properties and analysis of ChRM directions within and between sites allow the secure inference that the ChRM is a thermoremanent magnetization acquired during original cooling. The Eocene flows yield 15 independent samplings of the paleomagnetic field. However, these data fail the reversals test and probably do not adequately average geomagnetic secular variation. The Late Cretaceous flows yield 18 independent samplings of the paleomagnetic field, six of normal polarity and 12 of reversed polarity. These data pass the reversals test and have angular dispersion of virtual geomagnetic poles (VGPs) consistent with adequate sampling of geomagnetic secular variation. The mean of these 18 VGPs yields a Late Cretaceous paleomagnetic pole for South America: latitude = 78.7°S; longitude = 358.4°E; A95 = 6.3° (K = 31.6; S = 14.5°). This pole is consistent with similar age poles from North America and Africa when the Atlantic is reconstructed to 70 Ma. Contrary to previous indications, the South American apparent polar wander path does not reach the present rotation axis until after Late Cretaceous time.