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Article
Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases
Chemistry Faculty Research
  • Saikat Roy
  • Rosalynn Quiñones, Marshall University
Document Type
Article
Publication Date
3-12-2012
Abstract
Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral anti-cancer agent, are presented along with characterization by Raman spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. Solubility measurements conducted in water reveal the anhydrate has dramatically improved solubility compared to the commercial hydrate form. Finally, dasatinib is a rare example of a promiscuous solvate former and the basis for this behavior can now be understood by examining the poor packing efficiency in the unsolvated form.
Comments

The Version of Record is available from the publisher at http://pubs.acs.org/doi/abs/10.1021/cg300152p. Copyright © 2012 American Chemical Society. All rights reserved.

doi:10.1021/cg300152p

Citation Information
Roy, S.; Quiñones, R.; and Matzger, A. J. “Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases", Crystal Growth & Design, 2012, 12(4), 2122−2126.