I am interested in extensive statistical methods and applications to the research of biomedical science and public health. Two themes have been my current interest and from time to time they overlap with each other. The first one is theme is about making simultaneous inference on an ensemble of units, such as evaluating hospital profiling/ranking, various types of association evaluation in high-throughput genomic arrays; the other theme is the linear and nonlinear statistical methods that would be used to characterize nonlinear dose response relationship and the complex dynamics of biological systems.