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Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons
Development (2003)
  • Josette M. Ungos
  • Rolf O Karlstrom, University of Massachusetts - Amherst
  • David W. Raible
Abstract

Hedgehog (Hh) signal transduction is directly required in zebrafish DRG precursors for proper development of DRG neurons. Zebrafish mutations in the Hh signaling pathway result in the absence of DRG neurons and the loss of expression of neurogenin1 (ngn1), a gene required for determination of DRG precursors. Cell transplantation experiments demonstrate that Hh acts directly on DRG neuron precursors. Blocking Hh pathway activation at later stages of embryogenesis with the steroidal alkaloid, cyclopamine, further reveals that the requirement for a Hh signal response in DRG precursors correlates with the onset of ngn1 expression. These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors.

Disciplines
Publication Date
July 10, 2003
Publisher Statement

DOI: 10.1242/dev.00722

The published version is located at http://dev.biologists.org/content/130/22/5351.full


This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Generic License.
Citation Information
Josette M. Ungos, Rolf O Karlstrom and David W. Raible. "Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons" Development Vol. 130 Iss. 20 (2003)
Available at: http://works.bepress.com/rolf_karlstrom/11/