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Clearance and Excretion of Intratracheally and Orally Administered Aflatoxin B1 in the Rat
Food and Chemical Toxicology
  • Roger A. Coulombe, Jr., Utah State University
  • R. P. Sharma
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The pharmacokinetic disposition of intratracheally (i/t) and orally administered [3H]AFBt was studied in male Sprague-Dawley rats. Blood, urine and faeces were collected at selected intervals following administration of a single i/t or oral dose of AFB1 (600 μg/kg) in saline. Blood-concentration data from both groups approximated a two-compartment open model. The time-to-peak for the i/t group (hr) was less than that for the oral group (3 hr), but the disappearance of label from the blood followed a nearly identical course in both groups. The plasma half-lives (Image ) were 87.7 and 91.8 hr for the i/t and oral groups, respectively. In addition, urinary and faecal excretion profiles were similar. By day 23, urinary excretion of label had accounted for 16.4 and 15.0% of the dose in the i/t and oral groups, respectively, and faecal excretion for 56.0 and 54.6%. At this time, however, significantly more label was recovered from the lungs and upper airways of the rats of the i/t group than in those treated orally.

Originally published by Elsevier. Publisher's PDF available through remote link.
Citation Information
Coulombe, R.A. and R.P. Sharma (1985). Clearance and excretion of intratracheally and orally administered aflatoxin B1 in the rat. Food Chem. Toxicol. 23:827-830.