Article
¹⁶⁶Holmium-Containing Glass for Internal Radiotherapy of Tumors
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
Abstract
Aluminosilicate glass containing the β-emitter 166Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 μm fragments of 166Ho glass (200 μ Ci/tumor). The results suggest that 166Ho glass would be an effective modality for deposition of intense β- radiation for localized internal radiotherapy of tumors.
Department(s)
Biological Sciences
Second Department
Materials Science and Engineering
Keywords and Phrases
- glass,
- holmium 166,
- unclassified drug,
- DNA,
- radioisotope,
- animal experiment,
- breast carcinoma,
- cancer cell culture,
- cancer graft,
- controlled study,
- female,
- human cell,
- interstitial radiation,
- nude mouse,
- animal,
- brachytherapy,
- breast tumor,
- cancer transplantation,
- cell survival,
- metabolism,
- radiation exposure,
- Brachytherapy,
- Breast Neoplasms
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 1991 Elsevier, All rights reserved.
Publication Date
1-1-1991
Publication Date
01 Jan 1991
Disciplines
Citation Information
Roger F. Brown, Lisa C. Lindesmith and D. E. Day. "¹⁶⁶Holmium-Containing Glass for Internal Radiotherapy of Tumors" International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology Vol. 18 Iss. 7 (1991) p. 783 - 790 ISSN: 0883-2897 Available at: http://works.bepress.com/roger-brown/1/