Induction of Apoptosis in Fibroblasts by IL-1ß-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3Cell
AbstractThe mammalian interleukin-1β-converting enzyme (ICE) has sequence similarity to the C. elegans cell death gene ced-3. We show here that overexpression of the murine ICE (mICE) gene or of the C. elegans ced-3 gene causes Rat-1 cells to undergo programmed cell death. Point mutations in a region homologous between mICE and CED-3 eliminate the ability of mICE and ced-3 to cause cell death. The cell death caused by mICE can be suppressed by overexpression of the crmA gene, a specific inhibitor of ICE, as well as by bcl-2, a mammalian oncogene that can act to prevent programmed cell death. Our results suggest that ICE may function during mammalian development to cause programmed cell death.
- IL-1ß converting enzyme
Citation InformationMasayuki Miura, Hong Zhu, Rocco J. Rotello, Erika A. Hartwieg, et al.. "Induction of Apoptosis in Fibroblasts by IL-1ß-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3" Cell Vol. 75 Iss. 4 (1993) p. 653 - 660
Available at: http://works.bepress.com/rocco_rotello/36/