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Article
Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells
Proceedings of the National Academy of Sciences
  • Rocco J. Rotello, Cedarville University
  • Rita C. Lieberman, University of Colorado
  • Anthony F. Purchio, Oncogen
  • Lazaro E. Gerschenson, University of Colorado
Document Type
Article
Publication Date
4-15-1991
DOI
http://dx.doi.org/10.1073/pnas.88.8.3412
PubMed ID
2014262
PubMed Central® ID
PMC51457
Abstract

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

Keywords
  • Apoptosis
Citation Information
Rocco J. Rotello, Rita C. Lieberman, Anthony F. Purchio and Lazaro E. Gerschenson. "Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells" Proceedings of the National Academy of Sciences Vol. 88 Iss. 8 (1991) p. 3412 - 3415
Available at: http://works.bepress.com/rocco_rotello/33/