|Present||Associate Professor of Pharmaceutical Sciences, Cedarville University ‐ School of Pharmacy|
Honors and Awards
- Distinguished Alumni Award, Chadron State College - 2015
- Excellence in Education Award, Ohio Magazine - 2014
- Distinguished Young Alumni Award, Chadron State College - 1997
- Genetics & Pharmacogenomics
- Pharmaceutical Sciences-I
- Pharmacy and History
School of Pharmacy
Method for Treating Coronary Artery Disease Using Antibody Binding Human Protein Tyrosine Phosphatase Beta (HPTPβ) (2013)
A method of treating skeletal muscle or myocardial ischemia, stroke, coronary artery disease, or peripheral vascular disease, comprising administering to the subject an effective amount of an antibody or antigen-binding fragment thereof which binds HPTPbeta ...
Antibodies to the Staphylococcal Multidrug Resistance (SMR) Protein Pharmacy Faculty Patents (2005)
Described is a novel antibody to the Staphylococcal multidrug resistance (Smr) protein and a hybridoma cell line which produces that antibody. Also described are uses of the antibody, methods for its preparation, compositions comprising the ...
Web Publication (1)
Book Chapters (3)
Apoptosis: Definition, Roles, and Regulation Pharmaceutical Sciences Faculty Publications (1993)
The emergence of molecular biology, with the possibility of cloning genes and introducing them in cells where they are expressed, has challenged the classic concept of cell death. But that concept is still valid when ...
Journal Articles (12)
Activation of an Interleukin 1 Converting Enzyme Dependent Apoptosis Pathway by Granzyme B Proceedings of the National Academy of Sciences (1996)
Cytotoxic T lymphocytes (CTL) can induce apoptosis through a granzyme B-based killing mechanism. Here we show that in cells undergoing apoptosis by granzyme B, both p45 pro-interleukin 1 beta converting enzyme (ICE) and pro-CPP32 are ...
Functional Role of Interleukin 1ß (IL-1ß) in IL-1ß-converting Enzyme-mediated Apoptosis Journal of Experimental Medicine (1996)
Prointerleukin-1 beta (pro-IL-1 beta) is the only known physiologic substrate of the interleukin-1 beta (IL-1 beta)-converting enzyme (ICE), the founding member of the ICE/ced-3 cell death gene family. Since secreted mature IL-1 beta has been ...
Expression of Apogens and Engulfens During Programmed Cell Death in the Nervous System of the Chick Embryo Archives of Histology and Cytology (1995)
Two categories of cell death related to antigens, apogens and engulfens, have been reported to be expressed by apoptotic cells and the cells involved in their engulfment in the immune system, and in mesenchymal tissue ...
Expression of a Specific Marker of Avian Programmed Cell Death in Both Apoptosis and Necrosis Proceedings of the National Academy of Sciences (1994)
Apoptosis and necrosis are two types of cell death with different morphologic features. We report here the isolation of a monoclonal antibody, BV2, that specifically recognizes cells undergoing developmental programmed cell death in different tissues ...
Anti-Apogens and Anti-Engulfens: Monoclonal Antibodies Reveal Specific Antigens on Apoptotic and Engulfment Cells During Chicken Embryonic Development Development (1994)
We have isolated a group of monoclonal antibodies that specifically recognize either apoptotic or engulfment cells in the interdigit areas of chicken hind limb foot plates, and throughout the embryo. Ten of these antibodies (antiapogens) ...
Prevention of Vertebrate Neuronal Death by the crmA Gene Science (1994)
Interleukin-1β converting enzyme (ICE) is a mammalian homolog of CED-3, a protein required for programmed cell death in the nematode Caenorhabditis elegans. The activity of ICE can be specifically inhibited by the product of crmA, ...
Induction of Apoptosis in Fibroblasts by IL-1ß-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3 Cell (1993)
The mammalian interleukin-1β-converting enzyme (ICE) has sequence similarity to the C. elegans cell death gene ced-3. We show here that overexpression of the murine ICE (mICE) gene or of the C. elegans ced-3 gene causes ...
Characterization of Uterine Epithelium Apoptotic Cell Death Kinetics and Regulation by Progesterone and RU 486 The American Journal of Pathology (1992)
The authors show here that progesterone suppresses apoptosis, and its antagonist RU 486 induces it in rabbit uterine epithelium, as assessed by morphologic and biochemical studies. The authors' studies demonstrate that internucleosomal DNA fragments are ...
Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells Proceedings of the National Academy of Sciences (1991)
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial ...
Biochemical Evidence for Programmed Cell Death in Rabbit Uterine Epithelium The American Journal of Pathology (1989)
Uterine epithelial cell proliferation, differentiation, and death are known to be regulated by estrogen and progesterone. The authors investigated a specific pattern of cell death called apoptosis, or programmed cell death, which is biochemically characterized ...
Protein Analysis of Human Lacrimal Fluid in Varying Age Groups Excerpts in Pharmacy Research Journal
Purpose: The objective of this research project was to identify proteins secreted from human lacrimal fluids onto the extra-ocular surface of the eye that could be later used to predict eye health, disease, and age-related ...