In contrast to the classical design of a probe with one binding site to target one specific analyte, probes with multiple interaction sites or, alternatively, with single sites promoting tandem reactions to target one or multiple analytes, have been developed. They have been used in addressing the inherent challenges of selective targeting in the presence of structurally similar compounds and in complex matrices, as well as the visualization of the in vivo interaction or crosstalk between the analytes. Examples of analytes include reactive sulfur species, reactive oxygen species, nucleotides and enzymes. This review focuses on recent innovations in probe design, detection mechanisms and the investigation of biological processes. The vision is to promote the ongoing development of fluorescent probes to enable deeper insight into the physiology of bioactive analytes.
Article
Functional Synthetic Probes for Selective Targeting and Multi-analyte Detection and Imaging
Chemical Society Reviews
Sponsor
The authors thank the National Natural Science Foundation of China (no. 21775096, 21672131, 21705102), One hundred people plan of Shanxi Province, Shanxi Province “1331 project” Key Innovation Team Construction Plan Cultivation Team (2018-CT-1), Shanxi Province Foundation for Returnees (2017-026), the Shanxi Province Science Foundation for Youths (no. 201701D221061), Shanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related Wastes, China Institute for Radiation Production and Scientific Instrument Center of Shanxi University (201512).
Document Type
Citation
Publication Date
6-1-2019
Disciplines
Abstract
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DOI
10.1039/c8cs01006d
Persistent Identifier
https://archives.pdx.edu/ds/psu/30262
Citation Information
Yue, Y., Huo, F., Cheng, F., Zhu, X., Mafireyi, T., Strongin, R. M., & Yin, C. (2019). Functional synthetic probes for selective targeting and multi-analyte detection and imaging. Chemical Society Reviews, 48(15), 4155–4177.
In contrast to the classical design of a probe with one binding site to target one specific analyte, probes with multiple interaction sites or, alternatively, with single sites promoting tandem reactions to target one or multiple analytes, have been developed. They have been used in addressing the inherent challenges of selective targeting in the presence of structurally similar compounds and in complex matrices, as well as the visualization of the in vivo interaction or crosstalk between the analytes. Examples of analytes include reactive sulfur species, reactive oxygen species, nucleotides and enzymes. This review focuses on recent innovations in probe design, detection mechanisms and the investigation of biological processes. The vision is to promote the ongoing development of fluorescent probes to enable deeper insight into the physiology of bioactive analytes.