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Selected Works of Robert M. Strongin
Article
EL20, A Potent Antiarrhythmic Compound, Selectively Inhibits Calmodulin-Deficient Ryanodine Receptor Type 2
Heart Rhythm
  • Robert Klipp, Portland State University
  • Na Li, Baylor College of Medicine
  • Qiongling Wang, Baylor College of Medicine
  • Tarah A. Word, Baylor College of Medicine
  • Martha Sibrian-Vazquez, Portland State University
  • Robert M. Strongin, Portland State University
  • Xander H.T. Wehrens, Baylor College of Medicine
  • Jonathan Abramson, Portland State University
Find in your library
Document Type
Citation
Publication Date
4-1-2018
Disciplines
Abstract

This work provides a potential therapeutic mechanism for the development of antiarrhythmic compounds that inhibit leaky RyR2 resulting from CaM dissociation, which is often associated with failing hearts. Our data also suggest that CaM dissociation may contribute to the pathogenesis of arrhythmias with the CPVT-linked R176Q mutation.

Locate the Document
http://dx.doi.org/10.1016/j.hrthm.2017.12.017
DOI
10.1016/j.hrthm.2017.12.017
Persistent Identifier
https://archives.pdx.edu/ds/psu/25880
Citation Information
Klipp, R. C., Li, N., Wang, Q., Word, T. A., Sibrian-Vazquez, M., Strongin, R. M., ... & Abramson, J. J. (2017). EL20, A Potent Antiarrhythmic Compound, Selectively Inhibits Calmodulin Deficient Ryanodine Receptor Type 2. Heart rhythm, 15(4):578-586.