A series of geometrically well-defined cationic fluorophores were designed based on molecular mechanics. They contain biaryl linkers to impart rigidity preventing intramolecular folding between a conjugated biomolecule and fluorophore. All probes have absorption and emission maxima within 20 nm from Texas Red, as predicted by TDDFT calculations and validated experimentally.
Rhodamine Analogues for Molecular Ruler ApplicationsDyes and Pigments
SponsorThis work was supported by the National Institute on Deafness and Other Communication Disorders at the National Institutes of Health (R21 DC010231; R01 DC012588).
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Citation InformationYu-Hsuan Chu, Jorge O. Escobedo, Meiyan Jiang, Peter S. Steyger, Robert M. Strongin. (2016). Rhodamine analogs for molecular ruler applications, Dyes and Pigments, Volume 126, Pages 46-53.