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Article
Selective Fluorescence Detection of Cysteine and N-Terminal Cysteine Peptide Residues
Support from the National Institutes of Health via award RO1 EB002044 is gratefully acknowledged
  • Soojin Lim, Portland State University
  • Jorge O. Escobedo, Portland State University
  • Mark Lowry, Portland State University
  • Xiangyang Xu, Portland State University
  • Robert M. Strongin, Portland State University
Document Type
Post-Print
Publication Date
1-1-2010
Subjects
  • Supramolecular chemistry,
  • Cysteine -- Detection,
  • Fluorescent probes
Disciplines
Abstract
A new fluorogenic fluorescein derivative containing an α,β-unsaturated aldehyde moiety produces a selective fluorescent signal enhancement in the presence of cysteine or peptides containing N-terminal cysteine residues. The mechanism is based on synergistic covalent and supramolecular interactions.
Description

This is the author’s version of a work that was accepted for publication in Chemical Communications (Cambridge, England). Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Communications (Cambridge, England), 2010, 46(31):5707-9. doi: 10.1039/c0cc01398f.

Reproduced by permission of The Royal Society of Chemistry (RSC)

DOI
10.1039/c0cc01398f
Persistent Identifier
http://archives.pdx.edu/ds/psu/11117
Citation Information
Soojin Lim, Jorge O. Escobedo, Mark Lowry, Xiangyang Xu, et al.. "Selective Fluorescence Detection of Cysteine and N-Terminal Cysteine Peptide Residues" Support from the National Institutes of Health via award RO1 EB002044 is gratefully acknowledged (2010)
Available at: http://works.bepress.com/robert_strongin/4/