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Systemic Delivery and Biodistribution of Cisplatin in Vivo
Molecular Pharmaceutics
  • Yu-Hsuan Chu, Portland State University
  • Martha Sibrian-Vazquez, Portland State University
  • Jorge O. Escobedo, Portland State University
  • Amanda R. Phillips, Oregon Health & Science University
  • D. Thomas Dickey, Oregon Health & Science University
  • Qi Wang, Oregon Health & Science University
  • Martina Ralle, Oregon Health & Science University
  • Peter S. Steyger, Oregon Health & Science University
  • Robert M. Strongin, Portland State University
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Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin’s off-target effects, a new drug–fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

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Chu, Y., Sibrian-Vazquez, M., Escobedo, J. O., Phillips, A. R., Dickey, D. T., Wang, Q., & ... Strongin, R. M. (2016). Systemic Delivery and Biodistribution of Cisplatin in Vivo. Molecular Pharmaceutics, 13(8), 2677-2682.