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Article
The Locus Coeruleus and Central Chemosensitivity
Respiratory Physiology & Neurobiology
  • Luciane H. Gargaglioni
  • Lynn K. Hartzler, Wright State University - Main Campus
  • Robert W. Putnam, Wright State University - Main Campus
Document Type
Article
Publication Date
10-1-2010
Abstract
The locus coeruleus (LC) lies in the dorsal pons and supplies noradrenergic (NA) input to many regions of the brain, including respiratory control areas. The LC may provide tonic input for basal respiratory drive and is involved in central chemosensitivity since focal acidosis of the region stimulates ventilation and ablation reduces CO2-induced increased ventilation. The output of LC is modulated by both serotonergic and glutamatergic inputs. A large percentage of LC neurons are intrinsically activated by hypercapnia. This percentage and the magnitude of their response are highest in young neonates and decrease dramatically after postnatal day P10. The cellular bases for intrinsic chemosensitivity of LC neurons are comprised of multiple factors, primary among them being reduced extracellular and intracellular pH, which inhibit inwardly rectifying and voltage-gated K+ channels, and activate L-type Ca2+ channels. Activation of KCa channels in LC neurons may limit their ultimate response to hypercapnia. Finally, the LC mediates central chemosensitivity and contains pH-sensitive neurons in amphibians, suggesting that the LC has a long-standing phylogenetic role in respiratory control.
DOI
10.1016/j.resp.2010.04.024
Citation Information
Luciane H. Gargaglioni, Lynn K. Hartzler and Robert W. Putnam. "The Locus Coeruleus and Central Chemosensitivity" Respiratory Physiology & Neurobiology Vol. 173 Iss. 3 (2010) p. 264 - 273 ISSN: 1569-9048
Available at: http://works.bepress.com/robert_putnam/85/