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Contribution to Book
A Computer Model of Mammalian Central CO2 Chemoreception
Integration in Respiratory Control: From Genes to Systems
  • Mykyta M. Chernov
  • Robert W. Putnam, Wright State University - Main Campus
  • James C. Leiter
Document Type
Book Chapter
Publication Date
1-1-2008
Catalog Record
Catalog Record
Abstract
We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.
DOI
10.1007/978-0-387-73693-8_52
Citation Information
Mykyta M. Chernov, Robert W. Putnam and James C. Leiter. "A Computer Model of Mammalian Central CO2 Chemoreception" Integration in Respiratory Control: From Genes to Systems Vol. 605 (2008) p. 301 - 305 ISSN: 9780387736921
Available at: http://works.bepress.com/robert_putnam/127/