Article
Influence of caffeine on the repair of mitomycin C induced DNA damage
Food Biotechnology
(2003)
Abstract
Caffeine potentiated MMC induced lethality in Salmonella typhimurium strains proficient in excision and recombinant repair but not in excision or recombinant repair deficient strains. Caffeine was found to inhibit the removal of interstrand DNA crosslinks induced by MMC in strains proficient for excision repair but not in a strain deficient in excision repair. Our results indicate that the potentiation by caffeine of MMC induced lethality in S. typhimurium is primarily due to the inhibition by caffeine of excision repair of interstrand DNA crosslinks.
Keywords
- Caffeine,
- MMC,
- Mitomycin C,
- DNA damage,
- DNA repair
Disciplines
Publication Date
2003
Citation Information
Robert E. Levin and J. Kim. "Influence of caffeine on the repair of mitomycin C induced DNA damage" Food Biotechnology Vol. 17 Iss. 2 (2003) Available at: http://works.bepress.com/robert_levin/10/