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A case-control study of physical activity patterns and risk of non-fatal myocardial infarction
University of Massachusetts Medical School Faculty Publications
  • Jian Gong, Brown University
  • Hannia Campos, Harvard School of Public Health
  • Joseph Mark A. Fiecas, University of California, San Diego
  • Stephen T. McGarvey, Brown University
  • Robert J. Goldberg, University of Massachusetts Medical School
  • Caroline Richardson, University of Michigan - Ann Arbor
  • Ana Baylin, Brown University
UMMS Affiliation
Department of Quantitative Health Sciences; Meyers Primary Care Institute
Publication Date
Document Type
Aged; Case-Control Studies; Costa Rica; Female; *Health Behavior; Humans; Male; Middle Aged; *Motor Activity; Myocardial Infarction; Risk Assessment; Risk Factors

BACKGROUND: The interactive effects of different types of physical activity on cardiovascular disease (CVD) risk have not been fully considered in previous studies. We aimed to identify physical activity patterns that take into account combinations of physical activities and examine the association between derived physical activity patterns and risk of acute myocardial infarction (AMI).

METHODS: We examined the relationship between physical activity patterns, identified by principal component analysis (PCA), and AMI risk in a case-control study of myocardial infarction in Costa Rica (N=4172), 1994-2004. The component scores derived from PCA and total METS were used in natural cubic spline models to assess the association between physical activity and AMI risk.

RESULTS: Four physical activity patterns were retained from PCA that were characterized as the rest/sleep, agricultural job, light indoor activity, and manual labor job patterns. The light indoor activity and rest/sleep patterns showed an inverse linear relation (P for linearity=0.001) and a U-shaped association (P for non-linearity=0.03) with AMI risk, respectively. There was an inverse association between total activity-related energy expenditure and AMI risk but it reached a plateau at high levels of physical activity (P for non-linearity=0.01).

CONCLUSIONS: These data suggest that a light indoor activity pattern is associated with reduced AMI risk. PCA provides a new approach to investigate the relationship between physical activity and CVD risk.

  • Physical activity patterns,
  • Myocardial infarction,
  • Costa Rica
Rights and Permissions
Copyright 2013 Gong et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI of Published Version
Gong J, Campos H, Fiecas JM, McGarvey ST, Goldberg R, Richardson C, Baylin A. A case-control study of physical activity patterns and risk of non-fatal myocardial infarction. BMC Public Health. 2013 Feb 8;13:122. doi:10.1186/1471-2458-13-122. Link to article on publisher's site
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Link to Article in PubMed

PubMed ID
Citation Information
Jian Gong, Hannia Campos, Joseph Mark A. Fiecas, Stephen T. McGarvey, et al.. "A case-control study of physical activity patterns and risk of non-fatal myocardial infarction" Vol. 13 (2013) ISSN: 1471-2458 (Linking)
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