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Improved survival after heart failure: a community-based perspective
University of Massachusetts Medical School Faculty Publications
  • Samuel W. Joffe, University of Massachusetts Medical School
  • Kristy T. Webster, University of Massachusetts Medical School
  • David D. McManus, University of Massachusetts Medical School
  • Michael S. Kiernan, Tufts University School of Medicine
  • Darleen M. Lessard, University of Massachusetts Medical School
  • Jorge L. Yarzebski, University of Massachusetts Medical School
  • Chad E. Darling, University of Massachusetts Medical School
  • Joel M. Gore, University of Massachusetts Medical School
  • Robert J. Goldberg, University of Massachusetts Medical School
UMMS Affiliation
Department of Emergency Medicine; Department of Quantitative Health Sciences; Department of Medicine, Division of Cardiovascular Medicine; Meyers Primary Care Institute
Publication Date
5-15-2013
Document Type
Article
Subjects
Heart Failure; Survival Rate; Outcome Assessment (Health Care)
Abstract
BACKGROUND: Heart failure is a highly prevalent, morbid, and costly disease with a poor long-term prognosis. Evidence-based therapies utilized over the past 2 decades hold the promise of improved outcomes, yet few contemporary studies have examined survival trends in patients with acute heart failure. The primary objective of this population-based study was to describe trends in short- and long-term survival in patients hospitalized with acute decompensated heart failure (ADHF). A secondary objective was to examine patient characteristics associated with decreased long-term survival. METHODS AND RESULTS: We reviewed the medical records of 9748 patients hospitalized with ADHF at all 11 medical centers in central Massachusetts during 1995, 2000, 2002, and 2004. Patients hospitalized with ADHF were more likely to be elderly and to have been diagnosed with multiple comorbidities in 2004 compared with 1995. Over this period, survival was significantly improved in-hospital, and at 1, 2, and 5 years postdischarge. Five-year survival rates increased from 20% in 1995 to 29% in 2004. Although survival improved substantially over time, older patients and patients with chronic kidney disease, chronic obstructive pulmonary disease, anemia, low body mass index, and low blood pressures had consistently lower postdischarge survival rates than patients without these comorbidities. CONCLUSION: Between 1995 and 2004, patients hospitalized with ADHF have become older and increasingly comorbid. Although there has been a significant improvement in survival among these patients, their long-term prognosis remains poor, as fewer than 1 in 3 patients hospitalized with ADHF in 2004 survived more than 5 years.
Keywords
  • UMCCTS funding
Comments

Citation: Joffe SW, Webster K, McManus DD, Kiernan MS, Lessard D, Yarzebski J, Darling C, Gore JM, Goldberg RJ. Improved survival after heart failure: a community-based perspective. J Am Heart Assoc. 2013 May 15;2(3):e000053. doi:10.1161/JAHA.113.000053. Link to article on publisher's site

Copyright 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell. This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Medical student Kristy T. Webster participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
23676294
Citation Information
Samuel W. Joffe, Kristy T. Webster, David D. McManus, Michael S. Kiernan, et al.. "Improved survival after heart failure: a community-based perspective" Vol. 2 Iss. 3 (2013) ISSN: 2047-9980 (Linking)
Available at: http://works.bepress.com/robert_goldberg/380/