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Longitudinal study of implantable cardioverter-defibrillators: methods and clinical characteristics of patients receiving implantable cardioverter-defibrillators for primary prevention in contemporary practice
Meyers Primary Care Institute Publications and Presentations
  • Frederick A. Masoudi, University of Colorado
  • Alan S. Go, University of California, San Francisco
  • David J. Magid, University of Colorado
  • Andrea E. Cassidy-Bushrow, Henry Ford Hospital
  • Jonathan M. Doris, University of Southern California
  • Frances Fiocchi, University of Modena
  • Romel J. Garcia-Montilla, Marshfield Clinic
  • Karen A. Glenn, University of Iowa
  • Robert J. Goldberg, University of Massachusetts Medical School
  • Nigel Gupta, Kaiser Permanente
  • Jerry H. Gurwitz, University of Massachusetts Medical School
  • Stephen C. Hammill, Mayo Clinic
  • John J. Hayes, Marshfield Clinical Foundation for Medical Research and Education
  • Nicholas Jackson, University of Pennsylvania
  • Alan Kadish, Feinberg School of Medicine
  • M. Lauer
  • Allison W. Miller, Wake Forest University Health Sciences
  • D. Multerer
  • Pamela N. Peterson, Denver Health Medical Center
  • Liza M. Reifler, Denver Health and Hospital Authority
  • K. Reynolds
  • Jane S. Saczynski, University of Massachusetts Medical School
  • Claudio Schuger, Henry Ford Hospital
  • Param P. Sharma, St. Joseph's Hospital
  • David H. Smith, Kaiser Permanente
  • M. Suits
  • Shih-Hsien Sung, Taipei Veterans General Hospital
  • Paul D. Varosy, University of Colorado Denver
  • Humberto J. Vaidaillet, Marshfield Clinic Research Foundation
  • Robert T. Greenlee, Marshfield Clinic Research Foundation
UMMS Affiliation
Meyers Primary Care Institute; Department of Medicine, Division of Geriatric Medicine; Department of Quantitative Health Sciences
Date
11-1-2012
Document Type
Article
Medical Subject Headings
Defibrillators, Implantable
Abstract
Background- Implantable cardioverter-defibrillators (ICDs) are increasingly used for primary prevention after randomized, controlled trials demonstrating that they reduce the risk of death in patients with left ventricular systolic dysfunction. The extent to which the clinical characteristics and long-term outcomes of unselected, community-based patients with left ventricular systolic dysfunction undergoing primary prevention ICD implantation in a real-world setting compare with those enrolled in the randomized, controlled trials is not well characterized. This study is being conducted to address these questions. Methods and Results- The study cohort includes consecutive patients undergoing primary prevention ICD placement between January 1, 2006 and December 31, 2009 in 7 health plans. Baseline clinical characteristics were acquired from the National Cardiovascular Data Registry ICD Registry. Longitudinal data collection is underway, and will include hospitalization, mortality, and resource use from standardized health plan data archives. Data regarding ICD therapies will be obtained through chart abstraction and adjudicated by a panel of experts in device therapy. Compared with the populations of primary prevention ICD therapy randomized, controlled trials, the cohort (n=2621) is on average significantly older (by 2.5-6.5 years), more often female, more often from racial and ethnic minority groups, and has a higher burden of coexisting conditions. The cohort is similar, however, to a national population undergoing primary prevention ICD placement. Conclusions- Patients undergoing primary prevention ICD implantation in this study differ from those enrolled in the randomized, controlled trials that established the efficacy of ICDs. Understanding a broad range of health outcomes, including ICD therapies, will provide patients, clinicians, and policy makers with contemporary data to inform decision-making.
Comments

Citation: Circ Cardiovasc Qual Outcomes. 2012 Nov;5(6):e78-85. doi: 10.1161/CIRCOUTCOMES.112.965368. Link to article on publisher's site

Related Resources
Link to Article in PubMed
PubMed ID
23170006
Citation Information
Frederick A. Masoudi, Alan S. Go, David J. Magid, Andrea E. Cassidy-Bushrow, et al.. "Longitudinal study of implantable cardioverter-defibrillators: methods and clinical characteristics of patients receiving implantable cardioverter-defibrillators for primary prevention in contemporary practice" Vol. 5 Iss. 6 (2012) ISSN: 1941-7713 (Linking)
Available at: http://works.bepress.com/robert_goldberg/364/