Skip to main content
Article
Young patients hospitalized with an acute coronary syndrome
GRACE Publications
  • Hamza H. Awad, University of Massachusetts Medical School
  • David D. McManus, University of Massachusetts Medical School
  • Frederick A. Anderson, Jr., University of Massachusetts Medical School
  • Joel M. Gore, University of Massachusetts Medical School
  • Robert J. Goldberg, University of Massachusetts Medical School
UMMS Affiliation
Department of Quantitative Health Sciences; Meyers Primary Care Institute; Department of Medicine, Division of Cardiovascular Medicine; Center for Outcomes Research
Date
1-1-2013
Document Type
Article
Medical Subject Headings
Acute Coronary Syndrome; Hospitalization
Abstract

OBJECTIVES: Limited data are available describing the magnitude, clinical features, treatment practices, and short-term outcomes of younger adults hospitalized with an acute coronary syndrome (ACS).

METHODS: The objectives of this large multinational observational study were to describe recent trends in these and related endpoints among adult men and women younger than 55 years of age who were hospitalized with an ACS between 1999 and 2007 as part of the Global Registry of Acute Coronary Events (GRACE) study.

RESULTS: The overall proportion of young adults hospitalized with an ACS in our multinational study population was 23% (n=15 052 of 65 119); this proportion remained relatively constant during the years under study. The proportion of comparatively young patients hospitalized with a previous diagnosis of angina pectoris or heart failure decreased over time, whereas the rates of previously diagnosed hypertension in this patient population increased. The proportion of patients developing atrial fibrillation, heart failure, stroke, or an episode of major bleeding during hospitalization for an ACS decreased significantly over time. Both in-hospital (2.1% in 1999; 1.3% in 2007) and 30-day multivariable-adjusted death rates decreased by more than 30% (odds ratio=0.66, 95% confidence interval=0.60-0.74) during the years under study. The hospital use of effective cardiac therapies (e.g. angiotensin-converting enzyme inhibitors, beta-blockers) increased significantly over time.

CONCLUSION: The results of this large observational study provide insights into the magnitude, changing characteristics, and short-term outcomes of comparatively young adults hospitalized with an ACS. Decreasing rates of short-term mortality and important clinical complications likely reflect enhanced treatment efforts that warrant future monitoring.

Comments

Citation: Coron Artery Dis. 2013 Jan;24(1):54-60. doi: 10.1097/MCA.0b013e32835b0bf7. Link to article on publisher's site

Related Resources
Link to Article in PubMed
Keywords
  • UMCCTS funding
PubMed ID
23111585
Citation Information
Hamza H. Awad, David D. McManus, Frederick A. Anderson, Joel M. Gore, et al.. "Young patients hospitalized with an acute coronary syndrome" Vol. 24 Iss. 1 (2013) ISSN: 0954-6928 (Linking)
Available at: http://works.bepress.com/robert_goldberg/363/