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Article
Six-month outcomes in a multinational registry of patients hospitalized with an acute coronary syndrome (the Global Registry of Acute Coronary Events [GRACE])
Quantitative Health Sciences Publications and Presentations
  • Robert J. Goldberg, University of Massachusetts Medical School
  • Kristen Currie, University of Massachusetts Medical School
  • Kami White, University of Massachusetts Medical School
  • David Brieger
  • Phillippe Gabriel Steg, Centre Hospitalier Bichat-Claude Bernard
  • Shaun G. Goodman, University of Toronto
  • Omar H. Dabbous, University of Massachusetts Medical School
  • Keith A. A. Fox, University of Edinburgh
  • Joel M. Gore, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine, Center for Outcomes Research, Department of Surgery
Date
2-5-2004
Document Type
Article
Medical Subject Headings
Aged; Angina, Unstable; Australasia; Electrocardiography; Europe; Female; Follow-Up Studies; Hospitalization; Humans; International Cooperation; Male; Middle Aged; Myocardial Infarction; North America; Prospective Studies; Qualitative Research; *Registries; South America; Time Factors; Treatment Outcome
Abstract
Relatively limited data are available, particularly from the perspective of a multinational registry, about the post-discharge outcomes and management practices of patients with an acute coronary syndrome (ACS). The objectives of this longitudinal study were to examine 6-month outcomes in a large multinational sample of patients hospitalized with an ACS. A total of 5,476 patients with ST-segment elevation acute myocardial infarction (STEAMI), 5,209 patients with non-ST-segment elevation acute myocardial infarction (NSTEAMI), and 6,149 patients with unstable angina pectoris discharged from 90 hospitals in 14 countries comprised the study population. The study sample was recruited from 18 cluster sites in 14 countries that are currently collaborating in the Global Registry of Acute Coronary Events (GRACE) study. The 6-month post-discharge death rates were 4.8% in patients with STEAMI, 6.2% in patients with NSTEAMI, and 3.6% in patients with unstable angina pectoris. Approximately 1 in 5 of each of our comparison groups were rehospitalized for heart disease during the 6-month follow-up, and approximately 15% of each of the respective study cohorts underwent coronary revascularization during follow-up. Demographic and clinical characteristics of post-discharge decedents were identified according to type of ACS. Our results suggest that a considerable proportion of patients who were discharged from the hospital after an ACS, with some differences noted according to type of ACS, remain at increased risk for adverse outcomes during the relatively brief post-discharge period. These data suggest the need for better long-term medical management and more intense follow-up of patients with an ACS to improve their long-term outlook.
Rights and Permissions
Citation: Am J Cardiol. 2004 Feb 1;93(3):288-93. Link to article on publisher's site
Related Resources
Link to Article in PubMed
Citation Information
Robert J. Goldberg, Kristen Currie, Kami White, David Brieger, et al.. "Six-month outcomes in a multinational registry of patients hospitalized with an acute coronary syndrome (the Global Registry of Acute Coronary Events [GRACE])" Vol. 93 Iss. 3 (2004) ISSN: 0002-9149 (Linking)
Available at: http://works.bepress.com/robert_goldberg/278/