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Uses of the case-control and cohort epidemiological approaches in pediatric practice and research
Quantitative Health Sciences Publications and Presentations
  • Robert J. Goldberg, University of Massachusetts Medical School
  • Harris Pastides
  • R. Curtis Ellison
  • Robert W. Tuthill
  • Thomas DeWitt
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine
Publication Date
Document Type
Adolescent; Bronchitis; Child; *Epidemiologic Methods; Feeding Behavior; Humans; Infant; Infant, Newborn; *Pediatrics; Pneumonia; Prospective Studies; Retrospective Studies

Increasing reliance is being placed on the use of quantitative epidemiological methods in the conduct and evaluation of pediatric research. The basic design features of two common types of observational studies, the case-control study and the cohort study, are reviewed. Advantages and disadvantages of these two study designs are discussed with emphasis on aspects such as the selection of comparison groups, avoiding selection and recall bias, gathering exposure information, controlling for potentially confounding factors, and methods of analysis. Appreciation of the salient features of these study design approaches should aid the clinician/researcher in the conduct of research endeavors as well as in critically reviewing the medical literature.

Pediatr Res. 1985 Aug;19(8):787-90.
PubMed ID
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Link to Article in PubMed
Citation Information
Robert J. Goldberg, Harris Pastides, R. Curtis Ellison, Robert W. Tuthill, et al.. "Uses of the case-control and cohort epidemiological approaches in pediatric practice and research" Vol. 19 Iss. 8 (1985) ISSN: 0031-3998 (Linking)
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