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Article
MicroRNAs and Regeneration: Let-7 Members as Potential Regulators of Dedifferentiation in Lens and Inner Ear Hair Cell Regeneration of the Adult Newt
Biochemical and Biophysical Research Communications
  • Panagiotis A. Tsonis
  • Mindy K. Call
  • Matthew W. Grogg
  • Maureen A. Sartor
  • Ruth R. Taylor
  • Andrew Forge
  • Robert E.W. Fyffe, Wright State University
  • Robert Goldenberg
  • Richard Cowper-Sallari
  • Craig R. Tomlinson
Document Type
Article
Publication Date
11-3-2007
Abstract
MicroRNAs are known to regulate the expression of many mRNAs by binding to complementary target sequences at the 3′UTRs. Because of such properties, miRNAs may regulate tissue-specific mRNAs as a cell undergoes transdifferentiation during regeneration. We have tested this hypothesis during lens and hair cell regeneration in newts using microarray analysis. We found that distinct sets of miRNAs are associated with lens and hair cell regeneration. Members of the let-7 family are expressed in both events and they are regulated in a similar fashion. All the let-7 members are down regulated during the initiation of regeneration, which is characterized by dedifferentiation of terminally differentiated cells. This is the first report to correlate expression of miRNAs as novel regulators of vertebrate regeneration, alluding to a novel mechanism whereby transdifferentiation occurs.
DOI
10.1016/j.bbrc.2007.08.077
Citation Information
Panagiotis A. Tsonis, Mindy K. Call, Matthew W. Grogg, Maureen A. Sartor, et al.. "MicroRNAs and Regeneration: Let-7 Members as Potential Regulators of Dedifferentiation in Lens and Inner Ear Hair Cell Regeneration of the Adult Newt" Biochemical and Biophysical Research Communications Vol. 362 Iss. 4 (2007) p. 940 - 945 ISSN: 0006-291X
Available at: http://works.bepress.com/robert_fyffe/54/