This manual describes the HIV/AIDS risk reduction intervention developed by the Dayton/Columbus, Ohio, National AIDS Demonstration Research (NADR) Project for IDUs who are not in treatment and their sexual partners. This is the fourth in a series of HIV intervention manuals produced under the sponsorship of the Community Research Branch, DEPR. It is intended to provide program administrators, clinical staff, counselors, and others involved in AIDS education and prevention efforts with a complete set of procedures for providing intervention sessions on HIV disease, health-promoting behaviors, and building skills and developing personal commitment to HIV risk reduction.