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Selected Works of
Robert J. Barsotti
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Dr. Robert Barsotti is a Professor in the department of Neuroscience, Physiology, and Pharmacology.
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About Robert J. Barsotti
Dr. Robert Barsotti is a Professor in the department of Neuroscience, Physiology, and Pharmacology.
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Philadelphia College of Osteopathic Medicine
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Department of Bio-Medical Sciences
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Life Sciences
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Neuromuscular Function and Disease
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Cardiovascular Function and Disease
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Department of Bio-Medical Sciences
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Scholarly Articles
Contributions to Books
Conferences and Presentations
Thesis
Poster Presentations and Instructional Resources
Scholarly Articles
(32)
Article
The ADP release step of the smooth muscle cross-bridge cycle ...
Biophysical journal (1999)
J. A. Dantzig, Robert J. Barsotti, S. Manz, H. L. Sweeney, et al.
When smooth muscle myosin subfragment 1 (S1) is bound to actin filaments in vitro, the light chain domain tilts upon ...
Article
Laser photolysis of caged calcium: Rates of calcium release by ...
Biophysical journal (1996)
G. C. R. Ellis-Davies, J. H. Kaplan and Robert J. Barsotti
Nitrophenyl-EGTA and DM-nitrophen are Ca2+ cages that release Ca2+ when cleaved upon illumination with near-ultraviolet light. Laser photolysis of nitrophenyl-EGTA ...
Article
Myosin isoforms show different strokes for different blokes
Nature structural biology (1996)
Robert J. Barsotti, J. A. Dantzig and Y. E. Goldman
Spectroscopic evidence for tilting of smooth muscle, but not skeletal muscle, myosin heads when ADP dissociates suggests mechanisms for the ...
Article
Activation of skinned trabeculae of the guinea pig induced by ...
Biophysical journal (1994)
H. Martin and Robert J. Barsotti
The kinetics of force production in chemically skinned trabeculae from the guinea pig were studied by laser photolysis of caged ...
Article
Relaxation from rigor of skinned trabeculae of the guinea pig ...
Biophysical journal (1994)
H. Martin and Robert J. Barsotti
The kinetics of ATP-induced rigor cross-bridge detachment were studied by initiating relaxation in chemically skinned trabeculae of the guinea pig ...
Article
Mechanical and biochemical characterization of the contraction elicited by a ...
Experientia (1985)
U. Mrwa, K. Güth, J. C. Rüegg, R. J. Paul, et al.
The contraction induced by a Ca2+-independent myosin light chain kinase (MLCK-) was characterized in terms of isometric force (Fo), immediate ...
Article
Myosin light chain phosphorylation does not modulate cross-bridge cycling rate ...
Science (1983)
T. M. Butler, M. J. Siegman, S. U. Mooers and Robert J. Barsotti
An attempt was made to determine whether phosphorylation of the myosin light chain represents a thick filament-associated mechanism for modulating ...
Contributions to Books
(1)
Contribution to Book
Mitochondria in cell senescence: A Friend or Foe?
Advances in Protein Chemistry and Structural Biology (2023)
Qian Chen, Lindon H. Young and Robert J. Barsotti
Cell senescence denotes cell growth arrest in response to continuous replication or stresses damaging DNA or mitochondria. Mounting research suggests ...
OpenURL
Conferences and Presentations
(38)
Presentation
Cardioprotective effects of naltrindole in rat myocardial ischemia/reperfusion injury ...
Research Day (2023)
Logan Clair, Tanoh Boakye, James Ramsarran, Zinya Talukder, et al.
Myocardial infarction remains a major cause of mortality and morbidity globally and infarct size is a major determinant of prognosis. ...
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Presentation
Comparison of the inhibition of an OCT3 transporter inhibitor, Nilotinib ...
Research Day (2023)
Zachary G Tan, Juliet Melnik, Aakash Belsare, James Huang, et al.
Introduction Doxorubicin (DOX)-induced cardiotoxicity remains a significant barrier limiting its clinical application due to a lack of effective resolution. Targeting ...
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Presentation
Dual myristic acid and trans-activator of transcription conjugation of PKC ...
Research Day (2023)
James Ramsarran, Logan Clair, Taurai Augustin, Zinya Talukder, et al.
INTRODUCTION: Dual conjugation of PKC Beta II peptide inhibitor (PKCβII-) with myristic acid (myr) and trans-activator of transcription (Tat) (Myr-Tat-CC-SLNPEWNET ...
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Presentation
In vitro naltrindole mitigates phorbol 12-myristate 13-acetate induced superoxide release ...
Research Day (2023)
Devani A Johnson, Taylor A DiLisi, Juliet Melnik, Denise Pinto, et al.
Introduction: Naltrindole (NTI) is a selective delta opioid receptor antagonist that recently has been shown to be cardioprotective in both ...
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Presentation
Myristoylated Protein Kinase C Epsilon Peptide Inhibitor (Myr-PKC ε-) mitigates ...
Research Day (2023)
Zinya Talukder, Sunit G Singh, Alexis B Verwoert, Tameka C Dean, et al.
Introduction: Delayed graft function (DGF), a post-transplant acute kidney injury, occurs in one-third (~7000) of the total number of kidney ...
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Presentation
Pretreatment with Naltrindole Generates Dose Dependent Effects on Reduction of ...
Research Day (2023)
Annam Humayun, Sunit Singh, Arianna Gray, Devani Johnson, et al.
Over one million individuals experience a myocardial infarction (MI) every year. Currently, no therapeutic is available to salvage necrotic cardiac ...
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Presentation
Protein Kinase C Beta II Inhibitor combined with Conjugated Myristic ...
Research Day (2023)
Juliet M Melnik, Kayla Harrell, Arjun Nair, Desmond Boakye Tanoh, et al.
Introduction While timely reperfusion is critical during resuscitation of ischemic myocardium, oxidative stress still leads to ischemia/reperfusion (I/R) injury and ...
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Presentation
The effects of Mitoquinone on simulated ischemia/reperfusion injuries in ...
Research Day (2023)
Brittany Ott, Juliet Melnik, Meagan Lyons, Kimberly Dowes, et al.
Introduction: Reperfusion to an ischemic myocardium could result in damage termed myocardial ischemia/reperfusion (I/R) injury. Mitochondrial dysfunction is a major ...
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Presentation
The effects of mitoquinone pretreatment on doxorubicin-induced acute cardiac dysfunction
Research Day (2023)
Kimberly Dawes, Juliet Melnik, Meagan Lyons, Jonathan Amora, et al.
Introduction: Doxorubicin (DOX) is a widely used anti-cancer drug notorious for its irreversible cardiac toxicity. Currently, Dexrazoxane is the only ...
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Presentation
Mitochondrial Fission Contributes to Diaphragmatic Weakness Induced by Mechanical Ventilation
American Thoracic Society International Conference 2023 (2023)
Stephan Matecki, H Dridi, M Yehya, Robert J. Barsotti, et al.
In critical care patients, acute diaphragm unloading due to mechanical ventilation (MV) initiates a process of diaphragmatic dysfunction and atrophy ...
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Presentation
Dual conjugation of protein kinase C epsilon peptide inhibitor with ...
Research Day (2022)
Sunit Singh, Tameka C Dean, Desmond Boakye Tanoh, Kayla Harrell, et al.
Abstract Protein Kinase C epsilon (PKCε) signaling is known to mediate superoxide production from mitochondrial and uncoupled endothelial nitric oxide ...
Presentation
Infarct-sparing effects of naltrindole and analogues through inhibition of myocardial ...
Research Day (2022)
Desmond Boakye Tanoh, Logan Clair, Thomas Taylor, Sunit Singh, et al.
Coronary artery disease remains the leading cause of death worldwide. Reduction in infarct size may be a potential preventive strategy ...
Presentation
Intracellular Delivery of Protein Kinase C Beta II Peptide Inhibitor ...
Research Day (2022)
Logan Clair, James Ramsarran, Taurai Augustin, Cameron Stinson, et al.
INTRODUCTION: Peptides conjugated to myristic acid (myr) or trans activator of transcription (tat) have long been used to increase cell ...
Presentation
Myristic Acid-Trans-Activator of Transcription Dual Conjugation Enhances Intracellular delivery of ...
Research Day (2022)
Alexis B Verwoert, Sunit G Singh, Arjun Nair, Devani Johnson, et al.
Protein kinase C beta II (PKCβII) activation promotes polymorphonuclear (PMN) superoxide (SO) production by phosphorylating serine and threonine amino acid ...
Presentation
Pretreatment with Naltrindole Demonstrates Cardioprotection in an Acute In Vivo ...
Research Day (2022)
Annam Humayun, Sunit Singh, Arianna Gray, Devani Johnson, et al.
Myocardial infarctions (MI) remain prevalent in the U.S. with over one million cardiac events every year. Previous research indicates delta ...
Presentation
Renal function in a mouse model of acute kidney injury ...
Research Day (2022)
Alexis B Verwoert, Sunit G Singh, Tameka C Dean, Devani Johnson, et al.
Introduction: Delayed graft function (DGF) is a post-transplant acute kidney injury that is caused by prolonged ischemia resulting in oxidative ...
Presentation
The effects of ascorbic acid and sodium ascorbate on doxorubicin-induced ...
Research Day (2022)
Sasha Ghofrani, Kelly Annie Mercado, Nelma Malik, Kimberly Dawes, et al.
INTRODUCTION: Doxorubicin causes high superoxide levels in the mitochondria contributing to cardiotoxicity. Ascorbic acid (AA) and sodium ascorbate (SA) are ...
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