Article
Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways
Endocrine
ISBN or ISSN
1355-008X
Publication Date / Copyright Date
11-1-2019
Publisher
Springer Nature
DOI Number
10.1007/s12020-019-01930-z
Abstract
PURPOSE: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT
METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT
RESULTS: The BSA-Ang II conjugate was less potent competing for AT
CONCLUSIONS: Addition of a high molecular weight molecule to Ang II reduced its AT
Disciplines
Keywords
- AT1 receptor; Aldosterone release; Biased agonism; Bovine serum albumin-conjugated angiotensin II; Calcium mobilization; Salt appetite
Rights
© Springer Science + Business Media, LLC, part of Springer Nature 2019
Citation Information
Hong Weng Pang, Andrea Linares, Leena Couling, Jessica Santollo, et al.. "Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways" Endocrine Vol. 66 Iss. 2 (2019) p. 349 - 359 Available at: http://works.bepress.com/robert-speth/47/
This study was funded by a President’s Faculty Research Development Grant from Nova Southeastern University and the Cardiovascular Neuroscience Fund, Nova Southeastern University and NIH, HL-113905.