Article
Countering the classical renin-angiotensin system
Clinical Science
Document Type
Article
Publication Date
12-10-2021
Keywords
- Angiotensin-(1-7),
- Cardiovascular System,
- Renin-Angiotensin System,
- Sympathetic Nervous System,
- Transgenic Rat,
- Vasopressin
Disciplines
Abstract
It is well-established that Ang-(1-7) counteracts the effects of Ang II in the periphery, while stimulating vasopressin release and mimicking the activity of Ang II in the brain, through interactions with various receptors. The rapid metabolic inactivation of Ang-(1-7) has proven to be a limitation to therapeutic administration of the peptide. To circumvent this problem, Alves et al. (Clinical Science (2021) 135(18), https://doi.org/10.1042/CS20210599) developed a new transgenic rat model that overexpresses an Ang-(1-7)-producing fusion protein. In this commentary, we discuss potential concerns with this model while also highlighting advances that can ensue from this significant technical feat.
ORCID ID
0000-0002-6434-2136
DOI
10.1042/CS20211043
Copyright
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
Citation Information
Natalia M Noto, Yazmin M Restrepo and Robert C Speth. "Countering the classical renin-angiotensin system" Clinical Science Vol. 135 Iss. 23 (2021) p. 2619 - 2623 ISSN: 0143-5221 Available at: http://works.bepress.com/robert-speth/101/