Article
Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production
Journal of Biological Chemistry
Document Type
Article
Publication Date
10-26-2012
URL with Digital Object Identifier
10.1074/jbc.M112.366195
Disciplines
Abstract
Background: Aerobic glycolysis promotes resistance against Aβ toxicity. Results: Increased LDHA and PDK1 expression attenuates mitochondrial activity and confers resistance to Aβ. These proteins are down-regulated in a transgenic Alzheimer disease (AD) mouse model, and PDK1 is decreased in AD brain. Conclusion: PDK and LDHA are central mediators of Aβ resistance. Significance: Drugs that augment aerobic glycolysis may enhance brain cell survival in AD patients. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
Citation Information
Jordan T. Newington, Tim Rappon, Shawn Albers, Daisy Y. Wong, et al.. "Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production" Journal of Biological Chemistry Vol. 287 Iss. 44 (2012) p. 37245 - 37258 Available at: http://works.bepress.com/robert-cumming/3/