Associate Professor, Biology
Dr. Robert Cumming is a biologist investigating mechanisms of aging and neurodegenerative disorders, including Alzheimer's and Huntington's Disease. His research primarily regards aerobic glycolysis, or the transformation of glucose to lactate.
Asset Map Keywords: Memory and Learning, Brain Metabolism, and Neurodegenerative Disorders --> (see more)
Children's Health Collaborators: Dean Betts
Dr. Cumming also looks at antioxidant responses in animal models and cell culture, exploring the changes in brain metabolism and antioxidant defence that occur naturally with age and may contribute to the onset of cognitive decline and neurodegeneration. Additionally, Dr. Cumming's lab is investigating the role aerobic glycolysis plays in learning and memory using various transgenic mouse models with altered brain metabolism.
Led by Dr. Robert C. Cumming, our laboratory studies the changes in brain metabolism and antioxidant defence that occur with age. We are trying to understand how age-dependent alterations in metabolic and antioxidant enzyme activities contribute to neurodegenerative disorders, including Alzheimer’s disease and Huntington’s disease.
We currently are using a variety of biochemical, genetic, microscopic and neuroimaging techniques to examine aerobic glycolysis and antioxidant response in both cell culture and mouse models of aging and neurodegenerative diseases.
Our lab is equipped with a cell culture and microscopy suite, a wet lab with standard molecular and biochemical instrumentation, and a behavioural facility to test memory in rodents.
The Cumming lab focuses on mechanisms of aging and neurodegeneration. We are currently examining the role of aerobic glycolysis in regulating memory and susceptibility to neurotoxins in cell culture and mouse models of Alzheimer’s disease. We also study redox regulation of the antioxidant response in cell culture models of Huntington’s disease. In addition, we are determining the effect of expression of p66shc, a gene that regulates the level of reactive oxygen species (ROS) and lifespan in mammals, on redox processes linked to cytoskeletal remodeling. Metabolic reprogramming and regulation of ROS levels are now emerging as major determinates of aging and disease processes.
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About Robert Cumming
Dr. Robert Cumming is a biologist investigating mechanisms of aging and neurodegenerative disorders, including Alzheimer's and Huntington's Disease. His research primarily regards aerobic glycolysis, or the transformation of glucose to lactate.
Asset Map Keywords: Memory and Learning, Brain Metabolism, and Neurodegenerative Disorders --> (see more)
Children's Health Collaborators: Dean Betts
Dr. Cumming also looks at antioxidant responses in animal models and cell culture, exploring the changes in brain metabolism and antioxidant defence that occur naturally with age and may contribute to the onset of cognitive decline and neurodegeneration. Additionally, Dr. Cumming's lab is investigating the role aerobic glycolysis plays in learning and memory using various transgenic mouse models with altered brain metabolism.
Led by Dr. Robert C. Cumming, our laboratory studies the changes in brain metabolism and antioxidant defence that occur with age. We are trying to understand how age-dependent alterations in metabolic and antioxidant enzyme activities contribute to neurodegenerative disorders, including Alzheimer’s disease and Huntington’s disease.
We currently are using a variety of biochemical, genetic, microscopic and neuroimaging techniques to examine aerobic glycolysis and antioxidant response in both cell culture and mouse models of aging and neurodegenerative diseases.
Our lab is equipped with a cell culture and microscopy suite, a wet lab with standard molecular and biochemical instrumentation, and a behavioural facility to test memory in rodents.
The Cumming lab focuses on mechanisms of aging and neurodegeneration. We are currently examining the role of aerobic glycolysis in regulating memory and susceptibility to neurotoxins in cell culture and mouse models of Alzheimer’s disease. We also study redox regulation of the antioxidant response in cell culture models of Huntington’s disease. In addition, we are determining the effect of expression of p66shc, a gene that regulates the level of reactive oxygen species (ROS) and lifespan in mammals, on redox processes linked to cytoskeletal remodeling. Metabolic reprogramming and regulation of ROS levels are now emerging as major determinates of aging and disease processes.
| Present | Associate Professor, Western University ‐ Department of Biology | |
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| Present | Associate Scientist, Lawson Health Research Institute ‐ Children's Health Research Institute (CHRI) | |
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Disciplines
Research Interests
Memory and Learning, Brain Metabolism, Neurodegenerative Disorders, Cell and Molecular Biology, Proteomics, Alzheimer's Disease, Neurobiology, Genetics, Huntington’s Disease, Neuroimaging, Microscopy, Antioxidant Defence, Neuroprotective Agents, Lactate, Glucose, Aerobic Glycolysis, Animal Models, and Children's Health