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Article
Risk of pregnancy-related hypertension within 5 years of exposure to drinking water contaminated with Escherichia coli O157:H7
Journal of Clinical Hypertension
  • Louise Moist, Western University
  • Jessica M. Sontrop, Western University
  • Amit X. Garg, Western University
  • William F. Clark, Western University
  • Rita S. Suri, Western University
  • Robert Gratton, Western University
  • Marina Salvadori, London Health Sciences Centre
  • Immaculate Nevis, Western University
  • Jennifer J. Macnab, Western University
Document Type
Article
Publication Date
8-1-2010
URL with Digital Object Identifier
10.1111/j.1751-7176.2010.00288.x
Abstract

The authors evaluated the risk for pregnancy-related hypertension among previously healthy women who conceived within 5 years of exposure to drinking water contaminated with Escherichia coli O157.H7 in Walkerton, Canada (2000). Chronic hypertension was defined as systolic/diastolic blood pressure ≥140/90 mm Hg before 20 weeks gestation; gestational hypertension was defined as new onset systolic/diastolic blood pressure ≥140/90 mm Hg ≥20 weeks gestation. The incidence of hypertension was compared between women who were asymptomatic during the outbreak to those who experienced acute gastroenteritis. Blood pressure data were available for 135 of 148 eligible pregnancies. The adjusted relative risks for chronic and gestational hypertension were 1.5 (95% confidence interval [CI]: 0.3-7.7) and 1.0 (95% CI: 0.4-2.5), respectively. Mean arterial pressure before 20 weeks gestation was 2.7 mm Hg higher in women who had acute gastroenteritis (95% CI: 0.05-5.4). A trend toward higher chronic hypertension and mean arterial pressure in early pregnancy was observed among women who experienced gastroenteritis after exposure to bacterially-contaminated drinking water. © 2010 Wiley Periodicals, Inc.

Citation Information
Louise Moist, Jessica M. Sontrop, Amit X. Garg, William F. Clark, et al.. "Risk of pregnancy-related hypertension within 5 years of exposure to drinking water contaminated with Escherichia coli O157:H7" Journal of Clinical Hypertension Vol. 12 Iss. 8 (2010) p. 613 - 620
Available at: http://works.bepress.com/rob-grattton/2/