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Article
Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini
Journal of the American Chemical Society
  • Yu Liu
  • Akinori Kuzuya
  • Ruojie Sha
  • Johan Guillaume
  • Risheng Wang, Missouri University of Science and Technology
  • James W. Canary
  • Nadrian C. Seeman
Abstract

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. the product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

Department(s)
Chemistry
Keywords and Phrases
  • Catenane,
  • DNA Hybrid,
  • Oligonucleotide,
  • Denaturation,
  • DNA Cleavage,
  • DNA Helix,
  • DNA Strand,
  • DNA Structure,
  • DNA Template,
  • Stereoisomerism,
  • Synthesis,
  • Anthracenes,
  • DNA,
  • Molecular Structure,
  • Nucleic Acid Conformation,
  • Oligonucleotides,
  • Stereoisomerism,
  • Ultraviolet Rays
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2008 American Chemical Society (ACS), All rights reserved.
Publication Date
8-1-2008
Disciplines
Citation Information
Yu Liu, Akinori Kuzuya, Ruojie Sha, Johan Guillaume, et al.. "Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini" Journal of the American Chemical Society Vol. 130 Iss. 33 (2008) p. 10882 - 10883 ISSN: 0002-7863
Available at: http://works.bepress.com/risheng-wang/5/