Article
Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini
Journal of the American Chemical Society
Abstract
We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. the product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.
Department(s)
Chemistry
Keywords and Phrases
- Catenane,
- DNA Hybrid,
- Oligonucleotide,
- Denaturation,
- DNA Cleavage,
- DNA Helix,
- DNA Strand,
- DNA Structure,
- DNA Template,
- Stereoisomerism,
- Synthesis,
- Anthracenes,
- DNA,
- Molecular Structure,
- Nucleic Acid Conformation,
- Oligonucleotides,
- Stereoisomerism,
- Ultraviolet Rays
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2008 American Chemical Society (ACS), All rights reserved.
Publication Date
8-1-2008
Publication Date
01 Aug 2008
Disciplines
Citation Information
Yu Liu, Akinori Kuzuya, Ruojie Sha, Johan Guillaume, et al.. "Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini" Journal of the American Chemical Society Vol. 130 Iss. 33 (2008) p. 10882 - 10883 ISSN: 0002-7863 Available at: http://works.bepress.com/risheng-wang/5/