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Exploring the Addressability of DNA Decorated Multifunctional Gold Nanoparticles with DNA Origami Template
Bioconjugate Chemistry
  • Rachel Nixon
  • Wenyan Liu
  • Shuo Yang
  • Risheng Wang, Missouri University of Science and Technology

The hybridization of gold nanoparticles (AuNPs), along with other nanomaterials, has encouraged applications in biomedical imaging, plasmonic enhancement, and catalysts. However, the rational organization of AuNPs in nanotechnology fields remains difficult, which might require multiaddressability of nanoparticles for heterogeneous conjugation. In this work, multifunctional AuNPs were developed by conjugation of two types of DNA strands containing different sequences, which allowed the AuNPs to recognize multiple binding sites. The ratio of different sequences of DNA, and the different lengths of coding DNA oligos on the surface of the AuNPs, had varied influences on the functionality of the multifunctional DNA-AuNPs. This new type of DNA-decorated nanoparticles will enhance the diversity and complexity of nanoparticle-based bottom-up fabrication in materials science and bionanotechnology.

Keywords and Phrases
  • DNA,
  • gold nanoparticle,
  • metal nanoparticle,
  • nanomaterial,
  • oligomer, Article,
  • atomic force microscopy,
  • DNA sequence,
  • DNA strand,
  • DNA template,
  • hybridization,
  • nanotechnology
Document Type
Article - Journal
Document Version
File Type
© 2018 American Chemical Society (ACS), All rights reserved.
Publication Date
Citation Information
Rachel Nixon, Wenyan Liu, Shuo Yang and Risheng Wang. "Exploring the Addressability of DNA Decorated Multifunctional Gold Nanoparticles with DNA Origami Template" Bioconjugate Chemistry Vol. 29 Iss. 8 (2018) p. 2520 - 2525 ISSN: 1043-1802; 1520-4812
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