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Article
Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylation
Nature
  • Richard E. White, Philadelphia College of Osteopathic Medicine
  • Agnes Schonbrunn
  • David L. Armstrong
Document Type
Letter to the Editor
Publication Date
1-1-1991
Disciplines
Abstract

The neuropeptide somatostatin inhibits secretion from electrically excitable cells in the pituitary, pancreas, gut and brain. In mammalian pituitary tumour cells somatostatin inhibits secretion through two distinct pertussis toxin-sensitive mechanisms. One involves inhibition of adenylyl cyclase, the other an unidentified cyclic AMP-independent mechanism that reduces Ca2+ influx by increasing membrane conductance to potassium. Here we demonstrate that the predominant electrophysiological effect of somatostatin on metabolically intact pituitary tumour cells is a large, sustained increase in the activity of the large-conductance Ca2+- and voltage-activated K+ channels (BK). This action of somatostatin does not involve direct effects of Ca2+, cAMP or G proteins on the channels. Our results indicate instead that somatostatin stimulates BK channel activity through protein dephosphorylation.

Comments

This article was published in Nature, Volume 351, Issue 6327, Pages 570-573.

The published version is available at http://dx.doi.org/10.1038/351570a0 .

Copyright © 1991 NPG.

Citation Information
Richard E. White, Agnes Schonbrunn and David L. Armstrong. "Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylation" Nature Vol. 351 (1991) p. 570 - 573
Available at: http://works.bepress.com/richard_white/47/