Lysine Biosynthesis in Bacteria: A Metallodesuccinylase as a Potential Antimicrobial TargetJournal of Biological Inorganic Biochemistry
AbstractIn this review, we summarize the recent literature on dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) enzymes, with an emphasis on structure–function studies that provide insight into the catalytic mechanism. Crystallographic data have also provided insight into residues that might be involved in substrate and hence inhibitor recognition and binding. These data have led to the design and synthesis of several new DapE inhibitors, which are described along with what is known about how inhibitors interact with the active site of DapE enzymes, including the efficacy of a moderately strong DapE inhibitor.
Citation InformationDanuta Gillner, Daniel P. Becker and Richard C. Holz. "Lysine Biosynthesis in Bacteria: A Metallodesuccinylase as a Potential Antimicrobial Target" Journal of Biological Inorganic Biochemistry (2013) ISSN: 0949-8257
Available at: http://works.bepress.com/richard_holz/5/