Without a thorough understanding of culture and its nuances on part of the mental health service providers, alienation, stigma, and culturally based impediments rule. While concerns for diversity have been raised on numerous occasions, with increasing frequency over the past four decades, little progress has been made in implementing such concerns in clinical practice. Over two-thirds of Americans receive treatment for depression, anxiety, substance abuse, and related disorders. Comorbidity is rarely diagnosed. These trends are greatly exacerbated among members of ethnic, cultural, and linguistic minority groups. The authors contributing to this volume share their clinical acumen and experiences, rooted in their evidence-based research. Their purpose is to bring issues attending assessment and treatment of ethnic minority clientele closer to the fore. Some of the leading authors on the topic, in psychology and social work, present their well earned clinical and research experiences in this volume. Case studies are presented which are instructive and intriguing, bringing together the richness of a multidisciplinary approach to the topic.