SelectedWorks - Richard H. Perry

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Selected Works of Richard H. Perry

Associate Professor

For information on research interests and publications visit the web pages below:

[Perry Labs] [ORCID] [Research Gate] [Google Scholar]

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About Richard H. Perry

For information on research interests and publications visit the web pages below:

[Perry Labs] [ORCID] [Research Gate] [Google Scholar]

Theoretical study of the adsorption of analgesic environmental pollutants on pristine and nitrogen-doped graphene nanosheets (Richard Perry) Physical Chemistry Chemical Physics (2020)

Interactions of the analgesic medications dextropropoxyphene (DPP, opioid), paracetamol (PCL, nonnarcotic), tramadol (TDL, nonnarcotic), ibuprofen (IBN, nonsteroidal anti-inflammatory drug (NSAID)), and naproxen (NPX, NSAID) with pristine graphene (GN) and nitrogen-doped GN (NGN; containing only graphitic ...

Identification of Lipid Biomarkers of Metastatic Potential and Gene Expression (HER2/p53) in Human Breast Cancer Cell Cultures Using Ambient Mass Spectrometry (Heather Robison, Corryn E. Chini, Troy J. Comi, et al.) Analytical and Bioanalytical Chemistry (2020)

In breast cancer, overexpression of human epidermal growth factor receptor 2 (HER2) correlates with overactivation of lipogenesis, mutation of tumor suppressor p53, and increased metastatic potential. The mechanisms through which lipids mediate p53, HER2, and ...

Detection of a transient FeV(O)(OH) species involved in olefin oxidation by a bio-inspired non-haem iron catalyst (Shuangning Xu, Jedidiah J. Veach, Williamson N. Oloo, et al.) Chemical Communications (2018)

The Fe(TPA) (TPA = tris(pyridyl-2-methyl)amine) class of non-haem Fe catalysts is proposed to carry out selective hydrocarbon oxidations through the generation of high-valent iron species. Using ambient mass spectrometry, we obtain direct evidence for the ...

Synchronized Desorption Electrospray Ionization Mass Spectrometry Imaging (Troy J. Comi, Seung Woo Ryu and Richard H. Perry) Analytical Chemistry (2016)

Desorption electrospray ionization (DESI) has emerged as a powerful technique for mass spectral analysis and imaging under ambient conditions. Synchronization of DESI (sDESI) with the ion injection period (IT)of low-duty cycle mass spectrometers has been ...

Paper-Based Electrochemical Cell Coupled to Mass Spectrometry (Yao-Min Liu and Richard H. Perry) Journal of the American Society for Mass Spectrometry (2015)

On-line coupling of electrochemistry (EC) to mass spectrometry (MS) is a powerful approach for identifying intermediates and products of EC reactions in situ. In addition, EC transformations have been used to increase ionization efficiency and ...

Multistage Reactive Transmission-Mode Desorption Electrospray Ionization Mass Spectrometry (Kevin C. Peters, Troy J. Comi and Richard H. Perry) Journal of the American Society for Mass Spectrometry (2015)

Elucidating reaction mechanisms is important for advancing many areas of science such as catalyst development. It is often difficult to probe fast reactions at ambient conditions with high temporal resolution. In addition, systems involving reagents ...

Mass Spectrometry of Atmospheric-Pressure Ball Plasmoids (Scott E. Dubowsky, David M. Friday, Kevin C. Peters, et al.) International Journal of Mass Spectrometry (2015)

Ball lightning is a naturally occurring atmospheric event that has perplexed researchers for centuries, and there is to date no complete explanation (chemical, physical, or otherwise) as to why ball lightning behaves the way that ...

Electrooxidation of Alcohols Catalyzed by Amino Alcohol Ligated Ruthenium Complexes (Kristen R. Brownell, Charles C. L. McCrory, Christopher E. D. Chidsey, et al.) Journal of the American Chemical Society (2013)

Ruthenium transfer hydrogenation catalysts physisorbed onto edge-plane graphite electrodes are active electrocatalysts for the oxidation of alcohols. Electrooxidation of CH3OH (1.23 M) in a buffered aqueous solution at pH 11.5 with [(η6-p-cymene)(η2-N,O-(1R,2S)-cis-1-amino-2-indanol)]RuIICl (2) on edge-plane ...

Characterization of MYC-Induced Tumorigenesis by in Situ Lipid Profiling (Richard H. Perry, David I. Bellovin, Emelyn H. Shroff, et al.) Analytical Chemistry (2013)

We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This unique, label-free approach ...

Capturing Fleeting Intermediates in a Catalytic C-H Amination Reaction Cycle (Richard H. Perry, Thomas J. Cahill, Jennifer L. Roizen, et al.) Proceedings of the National Academy of Sciences of the United States of America (2012)

We have applied an ambient ionization technique, desorption electrospray ionization MS, to identify transient reactive species of an archetypal C–H amination reaction catalyzed by a dirhodium tetracarboxylate complex. Using this analytical method, we have detected ...

Transient Ru-Methyl Formate Intermediates Generated with Bifunctional Transfer Hydrogenation Catalysts (Richard H. Perry, Kristen R. Brownell, Konstantin Chingin, et al.) Proceedings of the National Academy of Sciences of the United States of America (2012)

Desorption electrospray ionization (DESI) coupled to high-resolution Orbitrap mass spectrometry (MS) was used to study the reactivity of a (β-amino alcohol)(arene)RuCl transfer hydrogenation catalytic precursor in methanol (CH3OH). By placing [(p-cymene)RuCl2]2 on a surface and ...

Generation of Melamine Polymer Condensates upon Hypergolic Ignition of Dicyanamide Ionic Liquids (Konstantin Chingin, Richard H. Perry, Steven D. Chambreau, et al.) Angewandte Chemie International Edition (2011)

The reaction of dicyanamide ionic liquids with nitric acid results in hypergolic ignition and the formation of a stable precipitate. The precipitate consists of cyclic triazines, including melamine and its polymers, such as melam and ...

Interfacing Capillary-Based Separations to Mass Spectrometry Using Desorption Electrospray Ionization (Griffin K. Barbula, Samir Safi, Konstantin Chingin, et al.) Analytical Chemistry (2011)

The powerful hybrid analysis method of capillary-based separations followed by mass spectrometric analysis gives substantial chemical identity and structural information. It is usually carried out using electrospray ionization. However, the salts and detergents used in ...

Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization (Richard H. Perry, Maurizio Splendore, Allis Chien, et al.) Angewandte Chemie International Edition (2011)

Capturing transient species: The bombardment of a surface‐bound RuII complex with charged droplets containing a ligand allows the detection of reaction intermediates (see figure). The reaction investigated is used to synthesize RuII catalysts containing amino ...

Trace Detection of Non-Uniformly Distributed Analytes on Surfaces Using Mass Transfer and Large-Area Desorption Electrospray Ionization (DESI) Mass Spectrometry (Santosh Soparawalla, Gary A. Salazar, Ewa Sokol, et al.) Analyst (2010)

Ambient ionization methods such as desorption electrospray ionization (DESI) allow the analysis of chemicals adsorbed at surfaces without the need for sample (or surface) pretreatment. A limitation of current implementations of these ionization sources is ...

Hand-Held Mass Spectrometer for Environmentally Relevant Analytes Using a Variety of Sampling and Ionization Methods (Nathaniel L. Sanders, Ewa Sokol, Richard H. Perry, et al.) European Journal of Mass Spectrometry (2010)

A recently developed hand-held, rectilinear ion trap mass spectrometer, capable of performing in situanalysis, has been evaluated for a variety of environmentally relevant analytes. Different sampling and ionization methods were implemented, demonstrating the considerable versatility ...

Rephasing Ion Packets in the Orbitrap Mass Analyzer to Improve Resolution and Peak Shape (Richard H. Perry, Qizhi Hu, Gary A. Salazar, et al.) Journal of The American Society for Mass Spectrometry (2009)

A method is described to improve resolution and peak shape in the Orbitrap under certain experimental conditions. In these experiments, an asymmetric anharmonic axial potential was first produced in the Orbitrap by detuning the voltage ...

Direct Analysis of Stevia Leaves for Diterpene Glycosides by Desorption Electrospray Ionization Mass Spectrometry (Ayanna U. Jackson, Alessandra Tata, Chunping Wu, et al.) Analyst (2009)

The analysis of Stevia leaves has been demonstrated without any sample preparation using desorption electrospray ionization (DESI) mass spectrometry. Direct rapid analysis was achieved using minimal amounts of sample (∼0.15 cm × 0.15 cm leaf ...

Pharmaceutical Cleaning Validation Using Non‐Proximate Large‐Area Desorption Electrospray Ionization Mass Spectrometry (Santosh Soparawalla, Gary A. Salazar, Richard H. Perry, et al.) Rapid Communications in Mass Spectrometry (2009)

Desorption electrospray ionization (DESI) is a droplet‐based ionization method that is applied to samples in the ambient environment with little or no sample preparation. Its utility for industrial applications is explored here for the case ...

Orbitrap Mass Spectrometry: Instrumentation, Ion Motion and Applications (Richard H. Perry, R. Graham Cooks and Robert J. Noll) Mass Spectrometry Reviews (2008)

Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely deliver high resolving power and mass accuracy. Unlike conventional ion traps such as the Paul and Penning traps, the ...

Liquid Chromatography with Dual Parallel Mass Spectrometry and 31P Nuclear Magnetic Resonance Spectroscopy for Analysis of Sphingomyelin and Dihydrosphingomyelin: II. Bovine Milk Sphingolipids (Wm. Craig Byrdwell and Richard H. Perry) Journal of Chromatography A (2007)

Liquid chromatography coupled to atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) mass spectrometry (MS), in parallel, was used for simultaneous detection of bovine milk sphingolipids (BMS). APCI-MS mass spectra exhibited mostly ceramide-like fragment ...

Serine Sublimes with Spontaneous Chiral Amplification (Richard H. Perry, Chunping Wu, Marcela Nefliu, et al.) Chemical Communications (2007)

Sublimation of near-racemic samples of serine yields a sublimate which is highly enriched in the major enantiomer; this simple one-step process occurs under relatively mild conditions, and represents a possible mechanism for the chiral amplification ...

Liquid Chromatography with Dual Parallel Mass Spectrometry and 31P Nuclear Magnetic Resonance Spectroscopy for Analysis of Sphingomyelin and Dihydrosphingomyelin: I. Bovine Brain and Chicken Egg Yolk (Wm. Craig Byrdwell and Richard H. Perry) Journal of Chromatography A (2006)

Liquid chromatography coupled to atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) mass spectrometry (MS), in parallel, was used for detection of bovine brain and chicken egg sphingolipids (SLs). APCI–MS mass spectra exhibited mostly ...

Ion Trajectory Simulations of Axial AC Dipolar Excitation in the Orbitrap (Guangxiang Wu, Robert J. Noll, Wolfgang R. Plass, et al.) International Journal of Mass Spectrometry (2006)

The newly developed version of the multi-particle ion trajectory simulation program, ITSIM 6.0, was applied to simulate ac dipolar excitation of ion axial motion in the Orbitrap. The Orbitrap inner and outer electrodes were generated ...

Halmos Undergraduate Co-Authors an Article in a Bioanalytical Chemistry Journal (Richard Perry) Sharkbytes (2020)