This paper characterizes changes in land use and forest cover in southern Cameroon. In doing so, we use remotely sensed data to define the rates and area of forest loss and cover change in two reference areas over a period of 16 years (from 1984 to 2000)—the Buea-Limbe area in the southwest province and the Bertoua area in the east province. We relate socio-economic data of these study areas with results from the empirical spatial analysis to explain causes of deforestation. A second set of explanations, which we call the theoretical perspective, attributes deforestation in southern Cameroon to the intricacies of modernization, world-systems, and neo-Malthusian theories.