Skip to main content
Local Anesthetics as Pain Therapy in Horses
Veterinary Clinics of North America (2010)
  • Reza Seddighi, DVM, MS, PhD, Dip ACVA, University of Tennessee - Knoxville

Local Anesthetics as Pain Therapy in Horses Thomas J. Doherty MVB, MSc, and M. Reza Seddighi DVM, PhD

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA

This article describes the rationale behind the use of systemically administered lidocaine as an analgesic. The analgesic efficacy of intravenously administered lidocaine is well documented by studies in human patients and laboratory animals. The mechanism by which systemically administered lidocaine produces analgesia is uncertain but is thought to include action at sodium, calcium, and potassium channels and the N-methyl-D-aspartate acid receptor. In addition, the anti-inflammatory actions of lidocaine are important in producing analgesia because inflammatory mediators augment neuronal excitability. The available studies of systemically administered lidocaine in horses provide evidence for the analgesic and anesthetic effects of intravenous lidocaine in this species.

Keywords: Lidocaine; Anesthesia; Antinociception; Horse

  • Pain management,
  • Horses,
  • Local anesthetics
Publication Date
Fall November 20, 2010
Citation Information
Reza Seddighi. "Local Anesthetics as Pain Therapy in Horses" Veterinary Clinics of North America Vol. 26 Iss. 3 (2010)
Available at: