Article
Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis
Organic & Biomolecular Chemistry
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
7-10-2020
DOI
10.1039/D0OB01422B
Abstract
The class II diterpene cyclase (DTC) from pleuromutilin biosynthesis uniquely mediates ‘A’ ring contraction of the initially formed decalin bicycle, yielding mutildienyl diphosphate (MPP). Catalysis requires a divalent metal cation co-factor. Intriguingly, selectively with magnesium, this DTC catalyzes ring expansion/contraction between MPP and halimadienyl diphosphate, providing some catalytic insight.
Creative Commons License
Creative Commons Attribution 3.0
Copyright Owner
The Royal Society of Chemistry
Copyright Date
2020
Language
en
File Format
application/pdf
Citation Information
Cody Lemke, Owen Whitham and Reuben J. Peters. "Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis" Organic & Biomolecular Chemistry Vol. 18 (2020) p. 5586 - 5588 Available at: http://works.bepress.com/reuben_peters/116/
This article is published as Lemke, Cody, Owen Whitham, and Reuben J. Peters. "Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis." Organic & Biomolecular Chemistry 18 (2020): 5586-5588. doi:10.1039/D0OB01422B.